TY  - JOUR
AU  - Decker, Nina Sophia
AU  - Johnson, Theron
AU  - Le Cornet, Charlotte
AU  - Behrens, Sabine
AU  - Obi, Nadia
AU  - Kaaks, Rudolf
AU  - Chang-Claude, Jenny
AU  - Fortner, Renée Turzanski
TI  - Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study.
JO  - Scientific reports
VL  - 14
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2024-00477
SP  - 4977
PY  - 2024
N1  - #EA:C020#LA:C020#
AB  - Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5-24.9 kg/m2: 51.7
KW  - Humans
KW  - Female
KW  - Oxysterols: metabolism
KW  - Cross-Sectional Studies
KW  - Breast Neoplasms: metabolism
KW  - Cholesterol: metabolism
KW  - Sterols
KW  - Phytosterols
KW  - Life Style
KW  - Oxysterols (NLM Chemicals)
KW  - Cholesterol (NLM Chemicals)
KW  - Sterols (NLM Chemicals)
KW  - Phytosterols (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38424253
C2  - pmc:PMC10904394
DO  - DOI:10.1038/s41598-024-55316-x
UR  - https://inrepo02.dkfz.de/record/288794
ER  -