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@ARTICLE{Decker:288794,
      author       = {N. S. Decker$^*$ and T. Johnson$^*$ and C. Le Cornet$^*$
                      and S. Behrens$^*$ and N. Obi and R. Kaaks$^*$ and J.
                      Chang-Claude$^*$ and R. T. Fortner$^*$},
      title        = {{A}ssociations between lifestyle, health, and clinical
                      characteristics and circulating oxysterols and cholesterol
                      precursors in women diagnosed with breast cancer: a
                      cross-sectional study.},
      journal      = {Scientific reports},
      volume       = {14},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2024-00477},
      pages        = {4977},
      year         = {2024},
      note         = {#EA:C020#LA:C020#},
      abstract     = {Despite increasing evidence that cholesterol precursors and
                      oxysterols, oxidized cholesterol metabolites, play a role in
                      numerous pathological processes and diseases including
                      breast cancer, little is known about correlates of these
                      sterols in women with breast cancer. In this study, 2282
                      women with breast cancer and blood draw post diagnosis were
                      included and cross-sectional associations between
                      circulating levels of 15 sterols/oxysterols and (a)
                      lifestyle, anthropometric, reproductive characteristics, (b)
                      comorbidities and medication use, and (c) breast cancer
                      tumor and treatment characteristics were calculated using
                      generalized linear models. Obesity was strongly associated
                      with circulating levels of 7-dehydrocholesterol (DC) (body
                      mass index ≥ 30 vs. 18.5-24.9 kg/m2: $51.7\%$ difference)
                      and 7-ketocholesterol (KC) $(40.0\%$ difference). After
                      adjustment for BMI, comorbidities such as cardiovascular
                      disease were associated with higher levels of 7-DC $(26.1\%$
                      difference) and lower levels of desmosterol (- $16.4\%$
                      difference). Breast cancer tumor characteristics including
                      hormone receptor status, tumor stage, and endocrine therapy
                      were associated with lanosterol, 24-DHLan, 7b-HC, and THC
                      (e.g., THC; tumor stage IIIa vs. I: $36.9\%$ difference).
                      Weaker associations were observed for lifestyle
                      characteristics and for any of the other oxysterols. The
                      findings of this study suggest that cholesterol precursors
                      are strongly associated with metabolic factors, while
                      oxysterols are associated with breast cancer tumor
                      characteristics, warranting further investigation into the
                      role of cholesterol precursors and oxysterols in women with
                      breast cancer and other populations.},
      keywords     = {Humans / Female / Oxysterols: metabolism / Cross-Sectional
                      Studies / Breast Neoplasms: metabolism / Cholesterol:
                      metabolism / Sterols / Phytosterols / Life Style /
                      Oxysterols (NLM Chemicals) / Cholesterol (NLM Chemicals) /
                      Sterols (NLM Chemicals) / Phytosterols (NLM Chemicals)},
      cin          = {C020},
      ddc          = {600},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38424253},
      pmc          = {pmc:PMC10904394},
      doi          = {10.1038/s41598-024-55316-x},
      url          = {https://inrepo02.dkfz.de/record/288794},
}