%0 Journal Article
%A Heisser, Thomas
%A Sergeev, Dmitry
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Contributions of early detection and cancer prevention to colorectal cancer mortality reduction by screening colonoscopy: a validated modelling study.
%J Gastrointestinal endoscopy
%V 100
%N 4
%@ 0016-5107
%C New York, NY
%I Elsevier
%M DKFZ-2024-00507
%P 710-717.e9
%D 2024
%Z #EA:C070#LA:C070#LA:C120# / 2024 Oct;100(4):710-717.e9
%X Screening colonoscopy, recommended every ten years, reduces mortality from colorectal cancer (CRC) by early detection of prevalent but undiagnosed CRC, as well as by prevention of CRC by removal of precursor lesions. The aim of this study was to assess the relative contribution of both components to total CRC mortality reduction over time.Using a validated multistate Markov model, we simulated hypothetical cohorts of 100,000 individuals aged 55-64 with and without use of screening at baseline. Main outcomes included proportions of prevented CRC deaths arising from (asymptomatic) CRC already prevalent at baseline and from newly developed CRC during 15-years of follow-up, and mortality rate ratios of screened versus unscreened groups over time.Early detection of prevalent cases accounted for 52
%K colonoscopy (Other)
%K colorectal cancer (Other)
%K endoscopy (Other)
%K modelling (Other)
%K mortality (Other)
%K screening (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38462054
%R 10.1016/j.gie.2024.03.010
%U https://inrepo02.dkfz.de/record/288860