000288879 001__ 288879
000288879 005__ 20250415112710.0
000288879 0247_ $$2doi$$a10.1038/s41467-024-46469-4
000288879 0247_ $$2pmid$$apmid:38472236
000288879 0247_ $$2altmetric$$aaltmetric:160710202
000288879 037__ $$aDKFZ-2024-00521
000288879 041__ $$aEnglish
000288879 082__ $$a500
000288879 1001_ $$0P:(DE-He78)391d81459dde44e1e2f63d940ce91a23$$aGalveias Casquinha Pires Martins, Leila$$b0$$eFirst author$$udkfz
000288879 245__ $$aSingle-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung.
000288879 260__ $$a[London]$$bNature Publishing Group UK$$c2024
000288879 3367_ $$2DRIVER$$aarticle
000288879 3367_ $$2DataCite$$aOutput Types/Journal article
000288879 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1710343152_32558
000288879 3367_ $$2BibTeX$$aARTICLE
000288879 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000288879 3367_ $$00$$2EndNote$$aJournal Article
000288879 500__ $$a#LA:B290#LA:B290#
000288879 520__ $$aUnderstanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung diseases. We combine mouse models allowing diphtheria toxin-mediated damage of specific epithelial cell types and parallel GFP-labeling of functionally dividing cells with single-cell transcriptomics to characterize the regeneration of the distal lung. We uncover cell types, including Krt13+ basal and Krt15+ club cells, detect an intermediate cell state between basal and goblet cells, reveal goblet cells as actively dividing progenitor cells, and provide evidence that adventitial fibroblasts act as supporting cells in epithelial regeneration. We also show that diphtheria toxin-expressing cells can persist in the lung, express specific inflammatory factors, and transcriptionally resemble a previously undescribed population in the lungs of COVID-19 patients. Our study provides a comprehensive single-cell atlas of the distal lung that characterizes early transcriptional and cellular responses to concise epithelial injury, encompassing proliferation, differentiation, and cell-to-cell interactions.
000288879 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
000288879 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000288879 7001_ $$0P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7$$aSieverling, Lina$$b1
000288879 7001_ $$0P:(DE-He78)a82f27613a3948cb34ebbd2408e9bb88$$aMichelhans, Michelle$$b2$$udkfz
000288879 7001_ $$0P:(DE-He78)94ceeae83286d24de236510234a0ef91$$aSchiller, Chiara$$b3
000288879 7001_ $$0P:(DE-He78)d7313b8a98b50ec1018453ef11351acc$$aErkut, Cihan$$b4$$udkfz
000288879 7001_ $$0P:(DE-He78)7a590ab95c6f7ba52880452da78ecd6c$$aGrünewald, Thomas$$b5$$udkfz
000288879 7001_ $$00000-0003-0370-7821$$aTriana, Sergio$$b6
000288879 7001_ $$0P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aFröhling, Stefan$$b7$$udkfz
000288879 7001_ $$00000-0002-1233-5874$$aVelten, Lars$$b8
000288879 7001_ $$0P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aGlimm, Hanno$$b9
000288879 7001_ $$0P:(DE-He78)2c1a21d1cf5fdc9e297512c9d1354250$$aScholl, Claudia$$b10$$eLast author$$udkfz
000288879 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-46469-4$$gVol. 15, no. 1, p. 2246$$n1$$p2246$$tNature Communications$$v15$$x2041-1723$$y2024
000288879 8564_ $$uhttps://inrepo02.dkfz.de/record/288879/files/s41467-024-46469-4.pdf
000288879 8564_ $$uhttps://inrepo02.dkfz.de/record/288879/files/s41467-024-46469-4.pdf?subformat=pdfa$$xpdfa
000288879 8767_ $$8SN-2024-00420-b$$92024-05-28$$d2025-04-14$$eAPC$$jZahlung erfolgt
000288879 909CO $$ooai:inrepo02.dkfz.de:288879$$pVDB$$pOpenAPC$$popenCost
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)391d81459dde44e1e2f63d940ce91a23$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a82f27613a3948cb34ebbd2408e9bb88$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)94ceeae83286d24de236510234a0ef91$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d7313b8a98b50ec1018453ef11351acc$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7a590ab95c6f7ba52880452da78ecd6c$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000288879 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)2c1a21d1cf5fdc9e297512c9d1354250$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000288879 9131_ $$0G:(DE-HGF)POF4-312$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunktionelle und strukturelle Genomforschung$$x0
000288879 9141_ $$y2024
000288879 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2022$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-05-02T09:09:09Z
000288879 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-05-02T09:09:09Z
000288879 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2023-05-02T09:09:09Z
000288879 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2023-05-02T09:09:09Z
000288879 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2022$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-08-29
000288879 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-08-29
000288879 915pc $$0PC:(DE-HGF)0000$$2APC$$aAPC keys set
000288879 915pc $$0PC:(DE-HGF)0001$$2APC$$aLocal Funding
000288879 915pc $$0PC:(DE-HGF)0002$$2APC$$aDFG OA Publikationskosten
000288879 915pc $$0PC:(DE-HGF)0003$$2APC$$aDOAJ Journal
000288879 9202_ $$0I:(DE-He78)B290-20160331$$kB290$$lAngewandte Funktionelle Genomik$$x0
000288879 9200_ $$0I:(DE-He78)B290-20160331$$kB290$$lAngewandte Funktionelle Genomik$$x0
000288879 9201_ $$0I:(DE-He78)B290-20160331$$kB290$$lAngewandte Funktionelle Genomik$$x0
000288879 9201_ $$0I:(DE-He78)B340-20160331$$kB340$$lTranslationale Medizinische Onkologie$$x1
000288879 9201_ $$0I:(DE-He78)B410-20160331$$kB410$$lTranslationale Pädiatrische Sarkomforschung$$x2
000288879 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x3
000288879 9201_ $$0I:(DE-He78)DD01-20160331$$kDD01$$lDKTK Koordinierungsstelle Dresden$$x4
000288879 9201_ $$0I:(DE-He78)B280-20160331$$kB280$$lB280 Translationale funktionelle Krebsgenomik$$x5
000288879 980__ $$ajournal
000288879 980__ $$aVDB
000288879 980__ $$aI:(DE-He78)B290-20160331
000288879 980__ $$aI:(DE-He78)B340-20160331
000288879 980__ $$aI:(DE-He78)B410-20160331
000288879 980__ $$aI:(DE-He78)HD01-20160331
000288879 980__ $$aI:(DE-He78)DD01-20160331
000288879 980__ $$aI:(DE-He78)B280-20160331
000288879 980__ $$aUNRESTRICTED
000288879 980__ $$aAPC