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@ARTICLE{GalveiasCasquinhaPiresMartins:288879,
      author       = {L. Galveias Casquinha Pires Martins$^*$ and L.
                      Sieverling$^*$ and M. Michelhans$^*$ and C. Schiller$^*$ and
                      C. Erkut$^*$ and T. Grünewald$^*$ and S. Triana and S.
                      Fröhling$^*$ and L. Velten and H. Glimm$^*$ and C.
                      Scholl$^*$},
      title        = {{S}ingle-cell division tracing and transcriptomics reveal
                      cell types and differentiation paths in the regenerating
                      lung.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-00521},
      pages        = {2246},
      year         = {2024},
      note         = {#LA:B290#LA:B290#},
      abstract     = {Understanding the molecular and cellular processes involved
                      in lung epithelial regeneration may fuel the development of
                      therapeutic approaches for lung diseases. We combine mouse
                      models allowing diphtheria toxin-mediated damage of specific
                      epithelial cell types and parallel GFP-labeling of
                      functionally dividing cells with single-cell transcriptomics
                      to characterize the regeneration of the distal lung. We
                      uncover cell types, including Krt13+ basal and Krt15+ club
                      cells, detect an intermediate cell state between basal and
                      goblet cells, reveal goblet cells as actively dividing
                      progenitor cells, and provide evidence that adventitial
                      fibroblasts act as supporting cells in epithelial
                      regeneration. We also show that diphtheria toxin-expressing
                      cells can persist in the lung, express specific inflammatory
                      factors, and transcriptionally resemble a previously
                      undescribed population in the lungs of COVID-19 patients.
                      Our study provides a comprehensive single-cell atlas of the
                      distal lung that characterizes early transcriptional and
                      cellular responses to concise epithelial injury,
                      encompassing proliferation, differentiation, and
                      cell-to-cell interactions.},
      cin          = {B290 / B340 / B410 / HD01 / DD01 / B280},
      ddc          = {500},
      cid          = {I:(DE-He78)B290-20160331 / I:(DE-He78)B340-20160331 /
                      I:(DE-He78)B410-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)DD01-20160331 / I:(DE-He78)B280-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38472236},
      doi          = {10.1038/s41467-024-46469-4},
      url          = {https://inrepo02.dkfz.de/record/288879},
}