000288986 001__ 288986
000288986 005__ 20250820132721.0
000288986 0247_ $$2doi$$a10.1016/j.ajcnut.2024.03.006
000288986 0247_ $$2pmid$$apmid:38479550
000288986 0247_ $$2ISSN$$a0095-9871
000288986 0247_ $$2ISSN$$a0002-9165
000288986 0247_ $$2ISSN$$a1938-3207
000288986 0247_ $$2ISSN$$a1938-3215
000288986 0247_ $$2altmetric$$aaltmetric:160633576
000288986 037__ $$aDKFZ-2024-00533
000288986 041__ $$aEnglish
000288986 082__ $$a570
000288986 1001_ $$aZheng, Ju-Sheng$$b0
000288986 245__ $$aDietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case-cohort study.
000288986 260__ $$aAmsterdam$$bElsevier$$c2024
000288986 3367_ $$2DRIVER$$aarticle
000288986 3367_ $$2DataCite$$aOutput Types/Journal article
000288986 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714983702_13242
000288986 3367_ $$2BibTeX$$aARTICLE
000288986 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000288986 3367_ $$00$$2EndNote$$aJournal Article
000288986 500__ $$a2024 May;119(5):1164-1174
000288986 520__ $$aEpidemiological evidence suggests that a potential association between dietary protein intake and cardiovascular disease (CVD) may depend on the protein source, i.e. plant- or animal- derived, but past research was limited and inconclusive.To evaluate the association of dietary plant- or animal-derived protein consumption with risk of CVD, and its components coronary heart disease (CHD) and stroke.This analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD case-cohort study included 16244 incident CVD cases (10784 CHD and 6423 stroke cases) and 15141 subcohort members from seven European countries. We investigated the association of estimated dietary protein intake with CVD, CHD and stroke (total, fatal and non-fatal) using multivariable-adjusted Prentice-weighted Cox regression. We estimated isocaloric substitutions of replacing fats and carbohydrates with plant- or animal-derived protein and replacing food-specific animal protein with plant protein. Multiplicative interactions between dietary protein and pre-specified variables were tested.Neither plant- nor animal-derived protein intake was associated with incident CVD, CHD or stroke in adjusted analyses without or with macronutrient-specified substitution analyses. Higher plant-derived protein intake was associated with 22% lower total stroke incidence among never smokers (HR 0.78, 95%CI: 0.62, 0.99), but not among current smokers (HR 1.08, 95%CI: 0.83, 1.40, p-interaction=0.004). Moreover, higher plant-derived protein (per 3% total energy) when replacing red meat protein (HR 0.52, 95%CI: 0.31, 0.88), processed meat protein (HR 0.39, 95%CI:0.17, 0.90) and dairy protein (HR 0.54, 95%CI:0.30, 0.98) was associated with lower incidence of fatal stroke.Plant- or animal-derived protein intake was not associated with overall CVD. However, the association of plant-derived protein consumption with lower total stroke incidence among non-smokers, and with lower incidence of fatal stroke highlights the importance of investigating CVD sub-types and potential interactions. These observations warrant further investigation in diverse populations with varying macronutrient intakes and dietary patterns.
000288986 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000288986 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000288986 650_7 $$2Other$$aanimal-derived protein
000288986 650_7 $$2Other$$acardiovascular disease
000288986 650_7 $$2Other$$acoronary heart disease
000288986 650_7 $$2Other$$aplant-derived protein
000288986 650_7 $$2Other$$astroke
000288986 7001_ $$aSteur, Marinka$$b1
000288986 7001_ $$aImamura, Fumiaki$$b2
000288986 7001_ $$aFreisling, Heinz$$b3
000288986 7001_ $$aJohnson, Laura$$b4
000288986 7001_ $$avan der Schouw, Yvonne T$$b5
000288986 7001_ $$aTong, Tammy Y N$$b6
000288986 7001_ $$aWeiderpass, Elisabete$$b7
000288986 7001_ $$0P:(DE-He78)0b48ce513fe49013263657450a12f870$$aBajracharya, Rashmita$$b8$$udkfz
000288986 7001_ $$aCrous-Bou, Marta$$b9
000288986 7001_ $$aDahm, Christina C$$b10
000288986 7001_ $$aHeath, Alicia K$$b11
000288986 7001_ $$aIbsen, Daniel B$$b12
000288986 7001_ $$aJannasch, Franziska$$b13
000288986 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b14$$udkfz
000288986 7001_ $$aMasala, Giovanna$$b15
000288986 7001_ $$aMoreno-Iribas, Conchi$$b16
000288986 7001_ $$aSacerdote, Carlotta$$b17
000288986 7001_ $$aSchulze, Matthias B$$b18
000288986 7001_ $$aSieri, Sabina$$b19
000288986 7001_ $$aWareham, Nicholas J$$b20
000288986 7001_ $$aDanesh, John$$b21
000288986 7001_ $$aButterworth, Adam S$$b22
000288986 7001_ $$aForouhi, Nita G$$b23
000288986 773__ $$0PERI:(DE-600)1496439-9$$a10.1016/j.ajcnut.2024.03.006$$gp. S0002916524003411$$n5$$p1164-1174$$tThe American journal of clinical nutrition$$v119$$x0095-9871$$y2024
000288986 8564_ $$uhttps://inrepo02.dkfz.de/record/288986/files/1-s2.0-S0002916524003411-main.pdf
000288986 8564_ $$uhttps://inrepo02.dkfz.de/record/288986/files/1-s2.0-S0002916524003411-main.pdf?subformat=pdfa$$xpdfa
000288986 909CO $$ooai:inrepo02.dkfz.de:288986$$pVDB
000288986 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0b48ce513fe49013263657450a12f870$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000288986 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000288986 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000288986 9141_ $$y2024
000288986 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bAM J CLIN NUTR : 2022$$d2023-10-21
000288986 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bAM J CLIN NUTR : 2022$$d2023-10-21
000288986 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0
000288986 980__ $$ajournal
000288986 980__ $$aVDB
000288986 980__ $$aI:(DE-He78)C020-20160331
000288986 980__ $$aUNRESTRICTED