TY  - JOUR
AU  - Zheng, Ju-Sheng
AU  - Steur, Marinka
AU  - Imamura, Fumiaki
AU  - Freisling, Heinz
AU  - Johnson, Laura
AU  - van der Schouw, Yvonne T
AU  - Tong, Tammy Y N
AU  - Weiderpass, Elisabete
AU  - Bajracharya, Rashmita
AU  - Crous-Bou, Marta
AU  - Dahm, Christina C
AU  - Heath, Alicia K
AU  - Ibsen, Daniel B
AU  - Jannasch, Franziska
AU  - Katzke, Verena
AU  - Masala, Giovanna
AU  - Moreno-Iribas, Conchi
AU  - Sacerdote, Carlotta
AU  - Schulze, Matthias B
AU  - Sieri, Sabina
AU  - Wareham, Nicholas J
AU  - Danesh, John
AU  - Butterworth, Adam S
AU  - Forouhi, Nita G
TI  - Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case-cohort study.
JO  - The American journal of clinical nutrition
VL  - 119
IS  - 5
SN  - 0095-9871
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2024-00533
SP  - 1164-1174
PY  - 2024
N1  - 2024 May;119(5):1164-1174
AB  - Epidemiological evidence suggests that a potential association between dietary protein intake and cardiovascular disease (CVD) may depend on the protein source, i.e. plant- or animal- derived, but past research was limited and inconclusive.To evaluate the association of dietary plant- or animal-derived protein consumption with risk of CVD, and its components coronary heart disease (CHD) and stroke.This analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD case-cohort study included 16244 incident CVD cases (10784 CHD and 6423 stroke cases) and 15141 subcohort members from seven European countries. We investigated the association of estimated dietary protein intake with CVD, CHD and stroke (total, fatal and non-fatal) using multivariable-adjusted Prentice-weighted Cox regression. We estimated isocaloric substitutions of replacing fats and carbohydrates with plant- or animal-derived protein and replacing food-specific animal protein with plant protein. Multiplicative interactions between dietary protein and pre-specified variables were tested.Neither plant- nor animal-derived protein intake was associated with incident CVD, CHD or stroke in adjusted analyses without or with macronutrient-specified substitution analyses. Higher plant-derived protein intake was associated with 22
KW  - animal-derived protein (Other)
KW  - cardiovascular disease (Other)
KW  - coronary heart disease (Other)
KW  - plant-derived protein (Other)
KW  - stroke (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38479550
DO  - DOI:10.1016/j.ajcnut.2024.03.006
UR  - https://inrepo02.dkfz.de/record/288986
ER  -