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000289079 245__ $$aSpatialData: an open and universal data framework for spatial omics.
000289079 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2025
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000289079 520__ $$aSpatially resolved omics technologies are transforming our understanding of biological tissues. However, the handling of uni- and multimodal spatial omics datasets remains a challenge owing to large data volumes, heterogeneity of data types and the lack of flexible, spatially aware data structures. Here we introduce SpatialData, a framework that establishes a unified and extensible multiplatform file-format, lazy representation of larger-than-memory data, transformations and alignment to common coordinate systems. SpatialData facilitates spatial annotations and cross-modal aggregation and analysis, the utility of which is illustrated in the context of multiple vignettes, including integrative analysis on a multimodal Xenium and Visium breast cancer study.
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000289079 7001_ $$aPalla, Giovanni$$b1
000289079 7001_ $$00000-0002-7818-1388$$aYamauchi, Kevin A$$b2
000289079 7001_ $$aVirshup, Isaac$$b3
000289079 7001_ $$0P:(DE-He78)38d5a76605dec0b5f883aca5bc39ee15$$aHeidari, Elyas$$b4$$udkfz
000289079 7001_ $$0P:(DE-He78)c351f5e9a33820bff921fe0f24829163$$aTreis, Tim$$b5$$udkfz
000289079 7001_ $$00000-0003-1666-5421$$aVierdag, Wouter-Michiel$$b6
000289079 7001_ $$aToth, Marcella$$b7
000289079 7001_ $$00009-0005-7712-8154$$aStockhaus, Sonja$$b8
000289079 7001_ $$aShrestha, Rahul B$$b9
000289079 7001_ $$00000-0002-4022-715X$$aRombaut, Benjamin$$b10
000289079 7001_ $$00000-0002-9509-9386$$aPollaris, Lotte$$b11
000289079 7001_ $$aLehner, Laurens$$b12
000289079 7001_ $$aVöhringer, Harald$$b13
000289079 7001_ $$0P:(DE-He78)0c219dbc36bb1df7df258d866ef48a80$$aKats, Ilia$$b14$$udkfz
000289079 7001_ $$00000-0002-0415-1506$$aSaeys, Yvan$$b15
000289079 7001_ $$00000-0002-5017-379X$$aSaka, Sinem K$$b16
000289079 7001_ $$00000-0002-0474-2218$$aHuber, Wolfgang$$b17
000289079 7001_ $$0P:(DE-He78)bf8843f36606c8735a840f6278fa1e90$$aGerstung, Moritz$$b18$$udkfz
000289079 7001_ $$00000-0003-4028-811X$$aMoore, Josh$$b19
000289079 7001_ $$00000-0002-2419-1943$$aTheis, Fabian J$$b20
000289079 7001_ $$0P:(DE-He78)9aabcfee1a1fc9202398a45a63f0b1e3$$aStegle, Oliver$$b21$$eLast author$$udkfz
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