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| 024 | 7 | _ | |a 10.1038/s41592-024-02212-x |2 doi |
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| 100 | 1 | _ | |a Marconato, Luca |0 P:(DE-He78)0f614b683f3f27ded03b1e6cc27d33d5 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a SpatialData: an open and universal data framework for spatial omics. |
| 260 | _ | _ | |a London [u.a.] |c 2025 |b Nature Publishing Group |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a #EA:B260#LA:B260# / 2025 Jan;22(1):58-62 |
| 520 | _ | _ | |a Spatially resolved omics technologies are transforming our understanding of biological tissues. However, the handling of uni- and multimodal spatial omics datasets remains a challenge owing to large data volumes, heterogeneity of data types and the lack of flexible, spatially aware data structures. Here we introduce SpatialData, a framework that establishes a unified and extensible multiplatform file-format, lazy representation of larger-than-memory data, transformations and alignment to common coordinate systems. SpatialData facilitates spatial annotations and cross-modal aggregation and analysis, the utility of which is illustrated in the context of multiple vignettes, including integrative analysis on a multimodal Xenium and Visium breast cancer study. |
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| 700 | 1 | _ | |a Palla, Giovanni |b 1 |
| 700 | 1 | _ | |a Yamauchi, Kevin A |0 0000-0002-7818-1388 |b 2 |
| 700 | 1 | _ | |a Virshup, Isaac |b 3 |
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| 700 | 1 | _ | |a Treis, Tim |0 P:(DE-He78)c351f5e9a33820bff921fe0f24829163 |b 5 |u dkfz |
| 700 | 1 | _ | |a Vierdag, Wouter-Michiel |0 0000-0003-1666-5421 |b 6 |
| 700 | 1 | _ | |a Toth, Marcella |b 7 |
| 700 | 1 | _ | |a Stockhaus, Sonja |0 0009-0005-7712-8154 |b 8 |
| 700 | 1 | _ | |a Shrestha, Rahul B |b 9 |
| 700 | 1 | _ | |a Rombaut, Benjamin |0 0000-0002-4022-715X |b 10 |
| 700 | 1 | _ | |a Pollaris, Lotte |0 0000-0002-9509-9386 |b 11 |
| 700 | 1 | _ | |a Lehner, Laurens |b 12 |
| 700 | 1 | _ | |a Vöhringer, Harald |b 13 |
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| 700 | 1 | _ | |a Saeys, Yvan |0 0000-0002-0415-1506 |b 15 |
| 700 | 1 | _ | |a Saka, Sinem K |0 0000-0002-5017-379X |b 16 |
| 700 | 1 | _ | |a Huber, Wolfgang |0 0000-0002-0474-2218 |b 17 |
| 700 | 1 | _ | |a Gerstung, Moritz |0 P:(DE-He78)bf8843f36606c8735a840f6278fa1e90 |b 18 |u dkfz |
| 700 | 1 | _ | |a Moore, Josh |0 0000-0003-4028-811X |b 19 |
| 700 | 1 | _ | |a Theis, Fabian J |0 0000-0002-2419-1943 |b 20 |
| 700 | 1 | _ | |a Stegle, Oliver |0 P:(DE-He78)9aabcfee1a1fc9202398a45a63f0b1e3 |b 21 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1038/s41592-024-02212-x |0 PERI:(DE-600)2163081-1 |n 1 |p 58-62 |t Nature methods |v 22 |y 2025 |x 1548-7091 |
| 856 | 4 | _ | |u https://inrepo02.dkfz.de/record/289079/files/s41592-024-02212-x.pdf |
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