%0 Journal Article
%A Sala, Elisa
%A Neagoie, Adela M
%A Lewerenz, Jan
%A Saadati, Maral
%A Benner, Axel
%A Gantner, Andrea
%A Wais, Verena
%A Döhner, Hartmut
%A Bunjes, Donald
%T Neurologic Complications of the Central Nervous System after Allogeneic Stem Cell Transplantation: The Role of Transplantation-Associated Thrombotic Microangiopathy as a Potential Underreported Cause. 
%J Transplantation and cellular therapy
%V 30
%N 6
%@ 2666-6375
%C [Amsterdam]
%I Elsevier B. V.
%M DKFZ-2024-00581
%P 586.e1-586.e11
%D 2024
%Z 2024 Jun;30(6):586.e1-586.e11
%X neurological complications (NC), especially those of the central nervous system (CNS), represent a severe complication after allogeneic stem cell transplantation (allo-HSCT) and are associated with relevant morbidity and mortality.we aim to characterize the potential risk factors for the development of CNS-NC with a special focus on the role of calcineurin inhibitors (CNI) as a predisposing factor. For this purpose, we compared Cyclosporin A (CsA) versus Tacrolimus (TAC) with respect to their influence on the incidence and type of CNS-NC after allo-HSCT.we retrospectively analyzed incidence, risk factors and impact on outcome of CNS-NC diagnosed during the post-transplantation follow-up in patients with different high-risk hematological malignancies who underwent allo-HSCT at our institution over a time frame of 20 years. All patients included in the analysis received CNI (CsA or TAC) as graft versus host disease (GVHD) prophylaxis.we evaluated a total of 739 consecutive patients transplanted from 12/1999 to 04/2019. Within a median follow-up period of 6.8 years, we observed a CNS-NC incidence of 17
%K allogeneic stem cell transplantation (Other)
%K neurological complications (Other)
%K tacrolimus (Other)
%K transplantation-associated thrombotic microangiopathy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38508452
%R 10.1016/j.jtct.2024.03.017
%U https://inrepo02.dkfz.de/record/289081