TY  - JOUR
AU  - Sala, Elisa
AU  - Neagoie, Adela M
AU  - Lewerenz, Jan
AU  - Saadati, Maral
AU  - Benner, Axel
AU  - Gantner, Andrea
AU  - Wais, Verena
AU  - Döhner, Hartmut
AU  - Bunjes, Donald
TI  - Neurologic Complications of the Central Nervous System after Allogeneic Stem Cell Transplantation: The Role of Transplantation-Associated Thrombotic Microangiopathy as a Potential Underreported Cause. 
JO  - Transplantation and cellular therapy
VL  - 30
IS  - 6
SN  - 2666-6375
CY  - [Amsterdam]
PB  - Elsevier B. V.
M1  - DKFZ-2024-00581
SP  - 586.e1-586.e11
PY  - 2024
N1  - 2024 Jun;30(6):586.e1-586.e11
AB  - neurological complications (NC), especially those of the central nervous system (CNS), represent a severe complication after allogeneic stem cell transplantation (allo-HSCT) and are associated with relevant morbidity and mortality.we aim to characterize the potential risk factors for the development of CNS-NC with a special focus on the role of calcineurin inhibitors (CNI) as a predisposing factor. For this purpose, we compared Cyclosporin A (CsA) versus Tacrolimus (TAC) with respect to their influence on the incidence and type of CNS-NC after allo-HSCT.we retrospectively analyzed incidence, risk factors and impact on outcome of CNS-NC diagnosed during the post-transplantation follow-up in patients with different high-risk hematological malignancies who underwent allo-HSCT at our institution over a time frame of 20 years. All patients included in the analysis received CNI (CsA or TAC) as graft versus host disease (GVHD) prophylaxis.we evaluated a total of 739 consecutive patients transplanted from 12/1999 to 04/2019. Within a median follow-up period of 6.8 years, we observed a CNS-NC incidence of 17
KW  - allogeneic stem cell transplantation (Other)
KW  - neurological complications (Other)
KW  - tacrolimus (Other)
KW  - transplantation-associated thrombotic microangiopathy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38508452
DO  - DOI:10.1016/j.jtct.2024.03.017
UR  - https://inrepo02.dkfz.de/record/289081
ER  -