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000289125 1001_ $$aCosta, Raquel L$$b0
000289125 245__ $$aHIHISIV: a database of gene expression in HIV and SIV host immune response.
000289125 260__ $$aHeidelberg$$bSpringer$$c2024
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000289125 520__ $$aIn the battle of the host against lentiviral pathogenesis, the immune response is crucial. However, several questions remain unanswered about the interaction with different viruses and their influence on disease progression. The simian immunodeficiency virus (SIV) infecting nonhuman primates (NHP) is widely used as a model for the study of the human immunodeficiency virus (HIV) both because they are evolutionarily linked and because they share physiological and anatomical similarities that are largely explored to understand the disease progression. The HIHISIV database was developed to support researchers to integrate and evaluate the large number of transcriptional data associated with the presence/absence of the pathogen (SIV or HIV) and the host response (NHP and human). The datasets are composed of microarray and RNA-Seq gene expression data that were selected, curated, analyzed, enriched, and stored in a relational database. Six query templates comprise the main data analysis functions and the resulting information can be downloaded. The HIHISIV database, available at https://hihisiv.github.io , provides accurate resources for browsing and visualizing results and for more robust analyses of pre-existing data in transcriptome repositories.
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000289125 650_7 $$2Other$$aHIV-1
000289125 650_7 $$2Other$$aHigh-throughput gene expression data
000289125 650_7 $$2Other$$aImmune response
000289125 650_7 $$2Other$$aSIV
000289125 7001_ $$0P:(DE-HGF)0$$aGadelha, Luiz$$b1
000289125 7001_ $$aD'arc, Mirela$$b2
000289125 7001_ $$aRibeiro-Alves, Marcelo$$b3
000289125 7001_ $$aRobertson, David L$$b4
000289125 7001_ $$aSchwartz, Jean-Marc$$b5
000289125 7001_ $$aSoares, Marcelo A$$b6
000289125 7001_ $$aPorto, Fábio$$b7
000289125 773__ $$0PERI:(DE-600)2041484-5$$a10.1186/s12859-024-05740-7$$gVol. 25, no. 1, p. 125$$n1$$p125$$tBMC bioinformatics$$v25$$x1471-2105$$y2024
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