TY  - JOUR
AU  - Costa, Raquel L
AU  - Gadelha, Luiz
AU  - D'arc, Mirela
AU  - Ribeiro-Alves, Marcelo
AU  - Robertson, David L
AU  - Schwartz, Jean-Marc
AU  - Soares, Marcelo A
AU  - Porto, Fábio
TI  - HIHISIV: a database of gene expression in HIV and SIV host immune response.
JO  - BMC bioinformatics
VL  - 25
IS  - 1
SN  - 1471-2105
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2024-00592
SP  - 125
PY  - 2024
AB  - In the battle of the host against lentiviral pathogenesis, the immune response is crucial. However, several questions remain unanswered about the interaction with different viruses and their influence on disease progression. The simian immunodeficiency virus (SIV) infecting nonhuman primates (NHP) is widely used as a model for the study of the human immunodeficiency virus (HIV) both because they are evolutionarily linked and because they share physiological and anatomical similarities that are largely explored to understand the disease progression. The HIHISIV database was developed to support researchers to integrate and evaluate the large number of transcriptional data associated with the presence/absence of the pathogen (SIV or HIV) and the host response (NHP and human). The datasets are composed of microarray and RNA-Seq gene expression data that were selected, curated, analyzed, enriched, and stored in a relational database. Six query templates comprise the main data analysis functions and the resulting information can be downloaded. The HIHISIV database, available at https://hihisiv.github.io , provides accurate resources for browsing and visualizing results and for more robust analyses of pre-existing data in transcriptome repositories.
KW  - HIV-1 (Other)
KW  - High-throughput gene expression data (Other)
KW  - Immune response (Other)
KW  - SIV (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38519883
DO  - DOI:10.1186/s12859-024-05740-7
UR  - https://inrepo02.dkfz.de/record/289125
ER  -