TY  - JOUR
AU  - Raut, Janhavi
AU  - Bhardwaj, Megha
AU  - Schöttker, Ben
AU  - Holleczek, Bernd
AU  - Schrotz-King, Petra
AU  - Brenner, Hermann
TI  - Cancer-specific risk prediction with a serum microRNA signature.
JO  - Cancer science
VL  - 115
IS  - 6
SN  - 1344-6428
CY  - Tokyo
PB  - Assoc.
M1  - DKFZ-2024-00595
SP  - 2049-2058
PY  - 2024
N1  - #EA:C070#LA:C070#LA:C120# / 2024 Jun;115(6):2049-2058
AB  - We recently derived and validated a serum-based microRNA risk score (miR-score) that predicted colorectal cancer (CRC) occurrence with very high accuracy within 14 years of follow-up in a population-based cohort study from Germany (ESTHER cohort). Here, we aimed to evaluate associations of the CRC-specific miR-score with the risk of developing other common cancers, including female breast cancer (BC), lung cancer (LC), and prostate cancer (PC), in the ESTHER cohort. MicroRNAs (miRNAs) were profiled by quantitative real-time PCR in serum samples collected at baseline from randomly selected incident cases of BC (n = 90), LC (n = 88), and PC (n = 93) and participants without diagnosis of CRC, LC, BC, or PC (controls, n = 181) until the end of the 17-year follow-up. Multivariate logistic regression models were used to evaluate the associations of the miR-score with BC, LC, and PC incidence. The miR-score showed strong inverse associations with BC and LC incidence [odds ratio per 1 standard deviation increase: 0.60 (95
KW  - breast cancer (Other)
KW  - circulating miRNA (Other)
KW  - colorectal cancer (Other)
KW  - lung cancer (Other)
KW  - prostate cancer (Other)
KW  - risk prediction (Other)
KW  - risk stratification (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38523358
DO  - DOI:10.1111/cas.16135
UR  - https://inrepo02.dkfz.de/record/289128
ER  -