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@ARTICLE{Reuss:289140,
      author       = {D. E. Reuss$^*$ and D. Schrimpf$^*$ and A. Cherkezov$^*$
                      and A. K. Suwala$^*$ and T. Lausová$^*$ and M. Snuderl and
                      D. Capper$^*$ and M. Sill$^*$ and D. T. W. Jones$^*$ and S.
                      M. Pfister$^*$ and F. Sahm$^*$ and A. von Deimling$^*$},
      title        = {{H}eterogeneity of {DNA} methylation profiles and copy
                      number alterations in 10782 adult-type glioblastomas,
                      {IDH}-wildtype.},
      journal      = {Free Neuropathology},
      volume       = {5},
      number       = {7},
      issn         = {2699-4445},
      address      = {Muenster},
      publisher    = {Prof. Dr. Werner Paulus, University of Muenster, Institute
                      of Neuropathology},
      reportid     = {DKFZ-2024-00607},
      pages        = {5-7},
      year         = {2024},
      note         = {#EA:B300#LA:B300# / 2024 Mar 22:5:5-7},
      abstract     = {The morphological patterns leading to the diagnosis of
                      glioblastoma may also commonly be observed in several other
                      distinct tumor entities, which can result in a mixed bag of
                      tumors subsumed under this diagnosis. The 2021 WHO
                      Classification of CNS Tumors has separated several of these
                      entities from the diagnosis of glioblastoma, IDH-wildtype.
                      This study determines the DNA methylation classes most
                      likely receiving the diagnosis glioblastoma, IDH wildtype
                      according to the definition by the WHO 2021 Classification
                      and provides comparative copy number analyses. We identified
                      10782 methylome datasets uploaded to the web page
                      www.molecularneuropathology.org with a calibrated score of
                      ≥0.9 by the Heidelberg Brain Tumor Classifier version
                      v12.8. These methylation classes were characterized by the
                      diagnosis glioblastoma being the most frequent
                      classification encountered in each of the classes according
                      to the WHO 2021 definition. Further, methylation classes
                      selected for this study predominantly contained adult
                      patients. Unsupervised clustering confirmed the presence of
                      nine methylation classes containing tumors most likely
                      receiving the diagnosis glioblastoma, IDH-wildtype according
                      to the WHO 2021 definition. Copy number analysis and a focus
                      on genes with typical numerical alterations in glioblastoma
                      revealed clear differences between the nine methylation
                      classes. Although great progress in diagnostic precision has
                      been achieved over the last decade, our data clearly
                      demonstrate that glioblastoma, IDH-wildtype still is a
                      heterogeneous group in need of further stratification.},
      keywords     = {7/10 signature (Other) / Amplification (Other) / CDKN2A/B
                      (Other) / CNV (Other) / Classification (Other) / Copy Number
                      Variations (Other) / EGFR (Other) / Glioblastoma (Other) /
                      Homozygous deletion (Other) / Methylation (Other)},
      cin          = {B300 / HD01 / BE01 / B062 / B360},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)BE01-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38532825},
      pmc          = {pmc:PMC10964111},
      doi          = {10.17879/FREENEUROPATHOLOGY-2024-5345},
      url          = {https://inrepo02.dkfz.de/record/289140},
}