%0 Journal Article
%A Tous, Sara
%A Guillamet, Mariona
%A Waterboer, Tim
%A Alemany, Laia
%A Paytubi, Sonia
%T Assessing the Potential of HPV16 E6 Seroprevalence as a Biomarker for Anal Dysplasia and Cancer Screening-A Systematic Review and Meta-Analysis.
%J International journal of molecular sciences
%V 25
%N 6
%@ 1422-0067
%C Basel
%I Molecular Diversity Preservation International
%M DKFZ-2024-00615
%P 3437
%D 2024
%X Elevated rates of human papillomavirus (HPV)-related anal high-grade squamous intraepithelial lesions (HSIL) and anal cancer (AC) in populations like men who have sex with men (MSM) living with HIV underscore the need for effective screening. While high-resolution anoscopy-guided biopsy is the gold standard, limited provider availability poses a challenge. This has spurred interest in identifying biomarkers for improved AC prevention. Antibodies against HPV16 oncoprotein E6, known as markers for cervical and oropharyngeal cancers, are the focus of the current study. The systematic review and meta-analysis included six studies meeting inclusion criteria, assessing HPV16 E6 seroprevalence in individuals with anal HSIL or AC. A two-step meta-analysis estimated pooled odds ratios and 95
%K HPV16 E6 (Other)
%K anal cancer (Other)
%K anal dysplasia (Other)
%K biomarkers (Other)
%K human papillomavirus (Other)
%K serology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38542409
%R 10.3390/ijms25063437
%U https://inrepo02.dkfz.de/record/289180