% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hauswald:289192,
      author       = {H. Hauswald$^*$ and E. Petrow$^*$ and F. Roeder$^*$ and J.
                      Debus and F. Zwicker$^*$ and P. Huber$^*$},
      title        = {{P}rimary and adjuvant intensity-modulated radiotherapy in
                      oropharyngeal carcinoma patients from a single institution.},
      journal      = {Journal of cancer research and therapeutics},
      volume       = {20},
      number       = {1},
      issn         = {0973-1482},
      address      = {Mumbai},
      publisher    = {Medknow Publications},
      reportid     = {DKFZ-2024-00626},
      pages        = {375 - 382},
      year         = {2024},
      note         = {#EA:E055#LA:E055#},
      abstract     = {To retrospectively access outcome, adverse events and
                      prognostic factors in oropharyngeal carcinoma (OPC) patients
                      treated with intensity-modulated radiotherapy
                      (IMRT).Ninety-eight OPC patients were treated between 2000
                      and 2015. Thirty-three patients received definitive and 65
                      adjuvant radiotherapy. Seventy-one percent had simultaneous
                      chemotherapy. Patients were systematically followed up (mean
                      114 months, range 19-197 months). Statistical analysis used
                      Kaplan-Meier method, Cox regression analysis, and log-rank
                      test. Adverse events were classified according to common
                      toxicity criteria version (CTCAE) 4.03.The 1-, 5-, and
                      10-year overall survival rates in the adjuvant vs.
                      definitive cohort were $90.8\%$ vs. $66.7\%,$ $67.4\%$ vs.
                      $33.1\%,$ and $57.7\%$ vs. $16.5\%.$ Survival in the
                      adjuvant cohort was significantly longer than in the
                      definitive cohort (P < 0.00005). Patients <65 years had a
                      significantly longer survival than older patients.
                      Locoregional tumor control rates after 1-, 5-, and 10 years
                      in the adjuvant vs. definitive cohort were $90.2\%$ vs.
                      $66.7\%,$ $82.2\%$ vs $45.4\%,$ and $72.1\%$ vs. $30.3\%.$
                      Locoregional tumor control in the adjuvant cohort was
                      significantly longer than in the definite cohort (P <
                      0.005). Distant metastases were diagnosed in $20.4\%$ of all
                      patients. Most patients had mild CTCAE grade 1 and 2 adverse
                      events and mild late adverse events including xerostomia,
                      dysphagia, and lymphedema.Intensity-modulated radiotherapy
                      for OPC is an important part of the treatment algorithm
                      alone and in particular after surgery while the additional
                      benefits of chemotherapy might be age dependent. Despite
                      advanced tumor stages, nearly half of our patients were
                      alive in the long term. The majority of patients had
                      relatively mild chronic adverse events.},
      keywords     = {Humans / Radiotherapy, Intensity-Modulated: adverse effects
                      / Radiotherapy, Intensity-Modulated: methods / Retrospective
                      Studies / Oropharyngeal Neoplasms: radiotherapy /
                      Oropharyngeal Neoplasms: drug therapy / Oropharyngeal
                      Neoplasms: pathology / Radiotherapy, Adjuvant: adverse
                      effects / Carcinoma: etiology},
      cin          = {E055},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38554349},
      doi          = {10.4103/jcrt.jcrt_2178_22},
      url          = {https://inrepo02.dkfz.de/record/289192},
}