TY  - JOUR
AU  - Tian, Yu
AU  - Lin, Yi
AU  - Qu, Conghui
AU  - Arndt, Volker
AU  - Baurley, James W
AU  - Berndt, Sonja I
AU  - Bien, Stephanie A
AU  - Bishop, D Timothy
AU  - Brenner, Hermann
AU  - Buchanan, Daniel D
AU  - Budiarto, Arif
AU  - Campbell, Peter T
AU  - Carreras-Torres, Robert
AU  - Casey, Graham
AU  - Chan, Andrew T
AU  - Chen, Rui
AU  - Chen, Xuechen
AU  - Conti, David V
AU  - Díez-Obrero, Virginia
AU  - Dimou, Niki
AU  - Drew, David A
AU  - Figueiredo, Jane C
AU  - Gallinger, Steven
AU  - Giles, Graham G
AU  - Gruber, Stephen B
AU  - Gunter, Marc J
AU  - Harlid, Sophia
AU  - Harrison, Tabitha A
AU  - Hidaka, Akihisa
AU  - Hoffmeister, Michael
AU  - Huyghe, Jeroen R
AU  - Jenkins, Mark A
AU  - Jordahl, Kristina M
AU  - Joshi, Amit D
AU  - Keku, Temitope O
AU  - Kawaguchi, Eric
AU  - Kim, Andre E
AU  - Kundaje, Anshul
AU  - Larsson, Susanna C
AU  - Marchand, Loic Le
AU  - Lewinger, Juan Pablo
AU  - Li, Li
AU  - Moreno, Victor
AU  - Morrison, John
AU  - Murphy, Neil
AU  - Nan, Hongmei
AU  - Nassir, Rami
AU  - Newcomb, Polly A
AU  - Obón-Santacana, Mireia
AU  - Ogino, Shuji
AU  - Ose, Jennifer
AU  - Pardamean, Bens
AU  - Pellatt, Andrew J
AU  - Peoples, Anita R
AU  - Platz, Elizabeth A
AU  - Potter, John D
AU  - Prentice, Ross L
AU  - Rennert, Gad
AU  - Ruiz-Narvaez, Edward A
AU  - Sakoda, Lori C
AU  - Schoen, Robert E
AU  - Shcherbina, Anna
AU  - Stern, Mariana C
AU  - Su, Yu-Ru
AU  - Thibodeau, Stephen N
AU  - Thomas, Duncan C
AU  - Tsilidis, Konstantinos K
AU  - van Duijnhoven, Franzel J B
AU  - Van Guelpen, Bethany
AU  - Visvanathan, Kala
AU  - White, Emily
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Wu, Anna H
AU  - Peters, Ulrike
AU  - Gauderman, W James
AU  - Hsu, Li
AU  - Chang-Claude, Jenny
TI  - Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk.
JO  - British journal of cancer
VL  - 130
IS  - 10
SN  - 0007-0920
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2024-00634
SP  - 1687-1696
PY  - 2024
N1  - #EA:C020#LA:C020# / 2024 Jun;130(10):1687-1696
AB  - Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk of colorectal cancer (CRC). To inform CRC risk prediction and MHT risk-benefit assessment, we aimed to evaluate the joint association of a polygenic risk score (PRS) for CRC and MHT on CRC risk.We used data from 28,486 postmenopausal women (11,519 cases and 16,967 controls) of European descent. A PRS based on 141 CRC-associated genetic variants was modeled as a categorical variable in quartiles. Multiplicative interaction between PRS and MHT use was evaluated using logistic regression. Additive interaction was measured using the relative excess risk due to interaction (RERI). 30-year cumulative risks of CRC for 50-year-old women according to MHT use and PRS were calculated.The reduction in odds ratios by MHT use was larger in women within the highest quartile of PRS compared to that in women within the lowest quartile of PRS (p-value = 2.7 × 10-8). At the highest quartile of PRS, the 30-year CRC risk was statistically significantly lower for women taking any MHT than for women not taking any MHT, 3.7
LB  - PUB:(DE-HGF)16
C6  - pmid:38561434
DO  - DOI:10.1038/s41416-024-02638-2
UR  - https://inrepo02.dkfz.de/record/289200
ER  -