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@ARTICLE{Zhou:289201,
      author       = {Y. Zhou and P. S. Ray and J. Zhu and F. Stein and M. Rettel
                      and T. Sekaran and S. Sahadevan and J. I. Perez-Perri and E.
                      K. Roth and O. Myklebost and L. A. Meza-Zepeda and A. von
                      Deimling$^*$ and C. Fu and A. N. Brosig and K. Boye and M.
                      Nathrath and C. Blattmann and B. Lehner and M. W. Hentze and
                      A. Kulozik$^*$},
      title        = {{S}ystematic analysis of {RNA}-binding proteins identifies
                      targetable therapeutic vulnerabilities in osteosarcoma.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-00635},
      pages        = {2810},
      year         = {2024},
      note         = {#LA:A400#},
      abstract     = {Osteosarcoma is the most common primary malignant bone
                      tumor with a strong tendency to metastasize, limiting the
                      prognosis of affected patients. Genomic, epigenomic and
                      transcriptomic analyses have demonstrated the exquisite
                      molecular complexity of this tumor, but have not
                      sufficiently defined the underlying mechanisms or identified
                      promising therapeutic targets. To systematically explore
                      RNA-protein interactions relevant to OS, we define the RNA
                      interactomes together with the full proteome and the
                      transcriptome of cells from five malignant bone tumors (four
                      osteosarcomata and one malignant giant cell tumor of the
                      bone) and from normal mesenchymal stem cells and
                      osteoblasts. These analyses uncover both systematic changes
                      of the RNA-binding activities of defined RNA-binding
                      proteins common to all osteosarcomata and individual
                      alterations that are observed in only a subset of tumors.
                      Functional analyses reveal a particular vulnerability of
                      these tumors to translation inhibition and a positive
                      feedback loop involving the RBP IGF2BP3 and the
                      transcription factor Myc which affects cellular translation
                      and OS cell viability. Our results thus provide insight into
                      potentially clinically relevant RNA-binding
                      protein-dependent mechanisms of osteosarcoma.},
      cin          = {B300 / HD01 / A400},
      ddc          = {500},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)A400-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38561347},
      doi          = {10.1038/s41467-024-47031-y},
      url          = {https://inrepo02.dkfz.de/record/289201},
}