TY  - JOUR
AU  - Trares, Kira
AU  - Wiesenfarth, Manuel
AU  - Stocker, Hannah
AU  - Perna, Laura
AU  - Petrera, Agnese
AU  - Hauck, Stefanie M
AU  - Beyreuther, Konrad
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer's disease and vascular dementia in a prospective study.
JO  - Immunity & ageing
VL  - 21
IS  - 1
SN  - 1742-4933
CY  - London
PB  - BioMed Central
M1  - DKFZ-2024-00657
SP  - 23
PY  - 2024
N1  - #EA:C070#LA:C070#
AB  - It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model.The Olink Target 96 Inflammation panel was assessed in a nested case-cohort design within a large, population-based German cohort study (n = 9940; age-range: 50-75 years). All study participants who developed dementia over 20 years of follow-up and had complete CAIDE variable data (n = 562, including 173 Alzheimer's disease (AD) and 199 vascular dementia (VD) cases) as well as n = 1,356 controls were selected for measurements. 69 inflammation-related biomarkers were eligible for use. LASSO logistic regression and bootstrapping were utilized to select relevant biomarkers and determine areas under the curve (AUCs).The CAIDE model 2 (including Apolipoprotein E (APOE) ε4 carrier status) predicted all-cause dementia, AD, and VD better than CAIDE model 1 (without APOE ε4) with AUCs of 0.725, 0.752 and 0.707, respectively. Although 20, 7, and 4 inflammation-related biomarkers were selected by LASSO regression to improve CAIDE model 2, the AUCs did not increase markedly. CAIDE models 1 and 2 generally performed better in mid-life (50-64 years) than in late-life (65-75 years) sub-samples of our cohort, but again, inflammation-related biomarkers did not improve their predictive abilities.Despite a lack of improvement in dementia risk prediction, the selected inflammation-related biomarkers were significantly associated with dementia outcomes and may serve as a starting point to further elucidate the pathogenesis of dementia.
KW  - Alzheimer’s disease (Other)
KW  - Cohort study (Other)
KW  - Dementia (Other)
KW  - Inflammation (Other)
KW  - Risk prediction (Other)
KW  - Vascular dementia (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38570813
DO  - DOI:10.1186/s12979-024-00427-2
UR  - https://inrepo02.dkfz.de/record/289223
ER  -