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000289229 1001_ $$aGil-Lespinard, Mercedes$$b0
000289229 245__ $$aPlasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort.
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000289229 520__ $$aDietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons.Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (-0.53 kg/5 years; 95% confidence interval [CI]: -0.99, -0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction.Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly)phenol biomarkers are needed to confirm these suggestive protective trends.
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000289229 650_7 $$2Other$$aBody weight
000289229 650_7 $$2Other$$aCohort
000289229 650_7 $$2Other$$aEPIC
000289229 650_7 $$2Other$$aNutritional biomarker
000289229 650_7 $$2Other$$aPlasma (poly)phenol
000289229 650_7 $$2NLM Chemicals$$aPhenols
000289229 650_7 $$0339NCG44TV$$2NLM Chemicals$$aPhenol
000289229 650_7 $$2NLM Chemicals$$aBiomarkers
000289229 650_2 $$2MeSH$$aHumans
000289229 650_2 $$2MeSH$$aPhenols
000289229 650_2 $$2MeSH$$aProspective Studies
000289229 650_2 $$2MeSH$$aPhenol
000289229 650_2 $$2MeSH$$aBody Weight
000289229 650_2 $$2MeSH$$aNeoplasms
000289229 650_2 $$2MeSH$$aBiomarkers
000289229 7001_ $$aAlmanza-Aguilera, Enrique$$b1
000289229 7001_ $$aCastañeda, Jazmín$$b2
000289229 7001_ $$aGuiñón-Fort, Daniel$$b3
000289229 7001_ $$aEriksen, Anne Kirstine$$b4
000289229 7001_ $$aTjønneland, Anne$$b5
000289229 7001_ $$aRothwell, Joseph A$$b6
000289229 7001_ $$aShah, Sanam$$b7
000289229 7001_ $$aCadeau, Claire$$b8
000289229 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b9$$udkfz
000289229 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron$$b10$$udkfz
000289229 7001_ $$aSchulze, Matthias B$$b11
000289229 7001_ $$aOliverio, Andreina$$b12
000289229 7001_ $$aPasanisi, Fabrizio$$b13
000289229 7001_ $$aTumino, Rosario$$b14
000289229 7001_ $$aManfredi, Luca$$b15
000289229 7001_ $$aMasala, Giovana$$b16
000289229 7001_ $$aSkeie, Guri$$b17
000289229 7001_ $$aLundblad, Marie Wasmuth$$b18
000289229 7001_ $$aBrustad, Magritt$$b19
000289229 7001_ $$aLasheras, Cristina$$b20
000289229 7001_ $$aCrous-Bou, Marta$$b21
000289229 7001_ $$aMolina-Montes, Esther$$b22
000289229 7001_ $$aColorado-Yohar, Sandra$$b23
000289229 7001_ $$aGuevara, Marcela$$b24
000289229 7001_ $$aAmiano, Pilar$$b25
000289229 7001_ $$aJohansson, Ingegerd$$b26
000289229 7001_ $$aHultdin, Johan$$b27
000289229 7001_ $$aForouhi, Nita G$$b28
000289229 7001_ $$aFreisling, Heinz$$b29
000289229 7001_ $$aMerdas, Mira$$b30
000289229 7001_ $$aDebras, Charlotte$$b31
000289229 7001_ $$aHeath, Alicia K$$b32
000289229 7001_ $$aAglago, Elom K$$b33
000289229 7001_ $$aAune, Dagfinn$$b34
000289229 7001_ $$aZamora-Ros, Raul$$b35
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