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@ARTICLE{GilLespinard:289229,
      author       = {M. Gil-Lespinard and E. Almanza-Aguilera and J. Castañeda
                      and D. Guiñón-Fort and A. K. Eriksen and A. Tjønneland
                      and J. A. Rothwell and S. Shah and C. Cadeau and V.
                      Katzke$^*$ and T. Johnson$^*$ and M. B. Schulze and A.
                      Oliverio and F. Pasanisi and R. Tumino and L. Manfredi and
                      G. Masala and G. Skeie and M. W. Lundblad and M. Brustad and
                      C. Lasheras and M. Crous-Bou and E. Molina-Montes and S.
                      Colorado-Yohar and M. Guevara and P. Amiano and I. Johansson
                      and J. Hultdin and N. G. Forouhi and H. Freisling and M.
                      Merdas and C. Debras and A. K. Heath and E. K. Aglago and D.
                      Aune and R. Zamora-Ros},
      title        = {{P}lasma {C}oncentration of 36 ({P}oly)phenols and
                      {P}rospective {B}ody {W}eight {C}hange in {P}articipants
                      from the {EPIC} {C}ohort.},
      journal      = {Annals of nutrition $\&$ metabolism},
      volume       = {80},
      number       = {2},
      issn         = {0250-6807},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {DKFZ-2024-00663},
      pages        = {87 - 100},
      year         = {2024},
      abstract     = {Dietary intake of (poly)phenols has been linked to reduced
                      adiposity and body weight (BW) in several epidemiological
                      studies. However, epidemiological evidence on (poly)phenol
                      biomarkers, particularly plasma concentrations, is scarce.
                      We aimed to investigate the associations between plasma
                      (poly)phenols and prospective BW change in participants from
                      the European Prospective Investigation into Cancer and
                      Nutrition (EPIC) cohort.This study included 761 participants
                      with data on BW at baseline and after 5 years of follow-up.
                      Plasma concentrations of 36 (poly)phenols were measured at
                      baseline using liquid chromatography-tandem mass
                      spectrometry. Associations were assessed through general
                      linear mixed models and multinomial logistic regression
                      models, using change in BW as a continuous or as a
                      categorical variable (BW loss, maintenance, gain),
                      respectively. Plasma (poly)phenols were assessed as
                      log2-transformed continuous variables. The false discovery
                      rate (FDR) was used to control for multiple
                      comparisons.Doubling plasma (poly)phenol concentrations
                      showed a borderline trend towards a positive association
                      with BW loss. Plasma vanillic acid showed the strongest
                      association (-0.53 kg/5 years; $95\%$ confidence interval
                      [CI]: -0.99, -0.07). Similar results were observed for
                      plasma naringenin comparing BW loss versus BW maintenance
                      (odds ratio: 1.1; $95\%$ CI: 1.0, 1.2). These results did
                      not remain significant after FDR correction.Higher
                      concentrations of plasma (poly)phenols suggested a tendency
                      towards 5-year BW maintenance or loss. While certain
                      associations seemed promising, they did not withstand FDR
                      correction, indicating the need for caution in interpreting
                      these results. Further studies using (poly)phenol biomarkers
                      are needed to confirm these suggestive protective trends.},
      keywords     = {Humans / Phenols / Prospective Studies / Phenol / Body
                      Weight / Neoplasms / Biomarkers / Body weight (Other) /
                      Cohort (Other) / EPIC (Other) / Nutritional biomarker
                      (Other) / Plasma (poly)phenol (Other) / Phenols (NLM
                      Chemicals) / Phenol (NLM Chemicals) / Biomarkers (NLM
                      Chemicals)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38272006},
      doi          = {10.1159/000535803},
      url          = {https://inrepo02.dkfz.de/record/289229},
}