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000289319 1001_ $$aUrban, Katharina$$b0
000289319 245__ $$aThe fentanyl-specific antibody FenAb024 can shield against carfentanil effects.
000289319 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2024
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000289319 500__ $$a#LA:D150# / Volume 396, 15 May 2024, Pages 1-10
000289319 520__ $$aThe surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic derivatives, has become a critical public health concern, which is particularly evident in the United States. While the situation is less severe in Europe, the European Monitoring Centre for Drugs and Drug Addiction reports a rise in drug overdose deaths, with emerging concerns about the impact of fentanyl-related molecules. Synthetic opioids, initially designed for medical use, have infiltrated illicit markets due to their low production costs and high potency, with carfentanil posing additional threats, including potential chemical weaponization. Existing overdose mitigation heavily relies on naloxone, requiring timely intervention and caregiver presence, while therapeutic prevention strategies face many access challenges. To provide an additional treatment option, we propose the use of a fentanyl-specific monoclonal antibody (mAb), as a non-opioid method of prophylaxis against fentanyl and carfentanil. This mAb shows protection from opioid effects in a pre-clinical murine model. mAbs could emerge as a versatile countermeasure in civilian and biodefense settings, offering a novel approach to combat opioid-associated mortality.
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000289319 650_7 $$2Other$$aOpioid crisis
000289319 650_7 $$2Other$$aantibody-associated protection
000289319 650_7 $$2Other$$acarfentanil
000289319 650_7 $$2Other$$afentanyl
000289319 650_7 $$2Other$$amonoclonal antibodies
000289319 650_7 $$2Other$$apassive immunization
000289319 7001_ $$aGkeka, Anastasia$$b1
000289319 7001_ $$aChandra, Monica$$b2
000289319 7001_ $$aGreiner, Dennis$$b3
000289319 7001_ $$aPollich, Selina$$b4
000289319 7001_ $$0P:(DE-He78)987a16a93296d4a043a1b2337d224b53$$aRuf, Sandra$$b5$$udkfz
000289319 7001_ $$aKelemen, Yosip$$b6
000289319 7001_ $$aSundermann, Tom$$b7
000289319 7001_ $$aPravetoni, Marco$$b8
000289319 7001_ $$aBaehr, Carly$$b9
000289319 7001_ $$0P:(DE-He78)3e1497ece09f8d2c69efc8b106a08f2b$$aStebbins, C Erec$$b10$$udkfz
000289319 7001_ $$0P:(DE-He78)79dbda58d51b613a0a421f579d2dfed3$$aPapavasiliou, F Nina$$b11$$udkfz
000289319 7001_ $$0P:(DE-He78)e13953968ed53b7fcae1139ac9ea7583$$aVerdi, Joseph Peter$$b12$$eLast author$$udkfz
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