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@ARTICLE{TurzanskiFortner:289332,
      author       = {R. Turzanski-Fortner$^*$ and K. D. Brantley and S. S.
                      Tworoger and R. M. Tamimi and B. Rosner and M. D. Holmes and
                      W. C. Willett and A. H. Eliassen},
      title        = {{R}ecreational physical activity and breast cancer risk by
                      menopausal status and tumor hormone receptor status: results
                      from the {N}urses' {H}ealth {S}tudies.},
      journal      = {Breast cancer research and treatment},
      volume       = {206},
      number       = {1},
      issn         = {0167-6806},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2024-00727},
      pages        = {77-90},
      year         = {2024},
      note         = {#EA:C020# / 2024 Jul;206(1):77-90},
      abstract     = {Physical activity is associated with lower breast cancer
                      risk, especially in postmenopausal women. Associations in
                      premenopausal women are less well established.We evaluated
                      recreational physical activity and breast cancer risk in the
                      Nurses' Health Study (NHS) and NHSII (187,278 women; n =
                      12,785 breast cancers; follow-up: NHS = 1986-2016, NHSII =
                      1989-2017) by menopausal status and estrogen (ER) and
                      progesterone (PR) receptor status. Physical activity was
                      evaluated as updated cumulative average of metabolic
                      equivalent of task (MET)-h/week. Cox proportional hazards
                      models were used to estimate multivariable hazard ratios
                      (HR) and $95\%$ confidence intervals (CI).Recreational
                      physical activity was inversely associated with breast
                      cancer risk in pre- and postmenopausal women. Higher
                      activity levels were associated with lower risk of ER+/PR +
                      breast cancer in both pre- and postmenopausal women (e.g.,
                      total recreational activity, ≥ 27 vs < 3 MET-h/week,
                      premenopausal HR = 0.83, $95\%CI$ = (0.70-0.99),
                      postmenopausal HR = 0.86 (0.78-0.95); pheterogeneity =
                      0.97). Results were attenuated with adjustment for current
                      body mass index (BMI) among postmenopausal, but not
                      premenopausal, women (e.g., ≥ 27 vs < 3 MET-h/week,
                      premenopausal HR = 0.83 (0.69-0.98); postmenopausal HR =
                      0.95 (0.85-1.05); pheterogeneity = 0.99). In analyses of
                      moderate-vigorous activity and breast cancer risk, no
                      heterogeneity by menopausal status was observed (phet ≥
                      0.53; e.g., ≥ 27 vs < 3 MET-h/week, ER+/PR+, premenopausal
                      HR = 0.88 (0.69-1.11); postmenopausal HR = 0.71 (0.58-0.88).
                      No associations were observed for ER-/PR-
                      disease.Recreational physical activity was associated with
                      lower breast cancer risk in both pre- and postmenopausal
                      women, supporting recreational physical activity as an
                      accessible, modifiable exposure associated with reduced
                      breast cancer risk regardless of menopausal status.},
      keywords     = {Breast cancer (Other) / Hormone receptor status (Other) /
                      Menopausal status (Other) / Physical activity (Other) / Risk
                      (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38592542},
      doi          = {10.1007/s10549-023-07238-x},
      url          = {https://inrepo02.dkfz.de/record/289332},
}