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000289461 1001_ $$aHolz, Anja$$b0
000289461 245__ $$aChildhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO).
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000289461 520__ $$aMultiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted.Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41-0.56), while overweight (HR 2.03; 95% CI 1.41-2.94) and obesity (HR 1.89; 95% CI 1.02-3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for ≤ 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40-0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors.Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.
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000289461 650_7 $$2Other$$aAdolescence
000289461 650_7 $$2Other$$aChildhood
000289461 650_7 $$2Other$$aEpidemiology
000289461 650_7 $$2Other$$aMultiple Sclerosis
000289461 650_2 $$2MeSH$$aHumans
000289461 650_2 $$2MeSH$$aAdolescent
000289461 650_2 $$2MeSH$$aMale
000289461 650_2 $$2MeSH$$aAdult
000289461 650_2 $$2MeSH$$aOverweight: epidemiology
000289461 650_2 $$2MeSH$$aMultiple Sclerosis: epidemiology
000289461 650_2 $$2MeSH$$aPediatric Obesity
000289461 650_2 $$2MeSH$$aExercise
000289461 7001_ $$aObi, Nadia$$b1
000289461 7001_ $$aAhrens, Wolfgang$$b2
000289461 7001_ $$aBerger, Klaus$$b3
000289461 7001_ $$aBohn, Barbara$$b4
000289461 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b5$$udkfz
000289461 7001_ $$aFischer, Beate$$b6
000289461 7001_ $$aFricke, Julia$$b7
000289461 7001_ $$aFührer, Amand$$b8
000289461 7001_ $$aGastell, Sylvia$$b9
000289461 7001_ $$0P:(DE-He78)e0ac0d57cdb66d87f2d95ae5f6178c1b$$aGreiser, Karin Halina$$b10$$udkfz
000289461 7001_ $$aHarth, Volker$$b11
000289461 7001_ $$aHeise, Jana-Kristin$$b12
000289461 7001_ $$aHolleczek, Bernd$$b13
000289461 7001_ $$aKeil, Thomas$$b14
000289461 7001_ $$aKlett-Tammen, Carolina J$$b15
000289461 7001_ $$aLeitzmann, Michael$$b16
000289461 7001_ $$aLieb, Wolfgang$$b17
000289461 7001_ $$aMeinke-Franze, Claudia$$b18
000289461 7001_ $$aMichels, Karin B$$b19
000289461 7001_ $$aMikolajczyk, Rafael$$b20
000289461 7001_ $$aNimptsch, Katharina$$b21
000289461 7001_ $$aPeters, Annette$$b22
000289461 7001_ $$aPischon, Tobias$$b23
000289461 7001_ $$aRiedel, Oliver$$b24
000289461 7001_ $$aSchikowski, Tamara$$b25
000289461 7001_ $$aSchipf, Sabine$$b26
000289461 7001_ $$aSchmidt, Börge$$b27
000289461 7001_ $$aSchulze, Matthias B$$b28
000289461 7001_ $$aStang, Andreas$$b29
000289461 7001_ $$aHellwig, Kerstin$$b30
000289461 7001_ $$aRiemann-Lorenz, Karin$$b31
000289461 7001_ $$aHeesen, Christoph$$b32
000289461 7001_ $$aBecher, Heiko$$b33
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