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@ARTICLE{Safi:289462,
      author       = {S. Safi and J. Krzykalla$^*$ and H. Hoffmann and A.
                      Benner$^*$ and H. Bischoff and M. Eichhorn and M. Kriegsmann
                      and I. Poschke and F. Stögbauer and L. Umansky$^*$ and C.
                      Mogler and W. Weichert and H. Winter and P. Beckhove and T.
                      Muley},
      title        = {{L}ow tumor interleukin-1β expression predicts a limited
                      effect of adjuvant platinum-based chemotherapy for patients
                      with completely resected lung adenocarcinoma: {A}n
                      identification and validation study.},
      journal      = {Pulmonology},
      volume       = {nn},
      issn         = {2531-0429},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-00784},
      pages        = {nn},
      year         = {2024},
      abstract     = {Adjuvant platinum-based chemotherapy for completely
                      resected non-small cell lung cancer is associated with
                      modest improvement in survival; nevertheless, no validated
                      biomarker exists for predicting the benefit or harm of
                      adjuvant platinum-based chemotherapy.We simultaneously
                      measured 27 cytokines in operative tumor specimens from a
                      discovery cohort (n = 97) by multiplex immunoassay; half of
                      the patients received adjuvant platinum-based chemotherapy,
                      and the other half were observed. We tested possible
                      prognostic and predictive factors in multivariate Cox models
                      for overall survival (OS) and relapse-free survival (RFS),
                      and a tree-based method was applied to detect predictive
                      factors with respect to RFS. The results were validated in
                      an independent validation cohort (n = 93).Fifty-two of 97
                      (54 $\%)$ patients in the discovery cohort and 50 of 93 (54
                      $\%)$ in the validation cohort received adjuvant
                      chemotherapy; forty-four (85 $\%)$ patients in the discovery
                      cohort and 37 (74 $\%)$ in the validation cohort received
                      four cycles as planned. In patients with low
                      IL-1β-expressing tumors, RFS and OS were worse after
                      adjuvant chemotherapy than after observation. The limited
                      effect of adjuvant chemotherapy for patients with low
                      IL-1β-expressing tumors was confirmed in the validation
                      cohort. Additionally, RFS and OS were prolonged by adjuvant
                      chemotherapy only in patients with high IL-1β-expressing
                      tumors in the validation cohort.This study identified and
                      validated low tumor IL-1β expression as a potential
                      biomarker of a limited response to adjuvant platinum-based
                      chemotherapy after complete resection of pulmonary
                      adenocarcinoma. This finding has the potential to inform
                      adjuvant treatment decisions.},
      keywords     = {Biomarkers (Other) / Cytokines (Other) / IL-1β (Other) /
                      Lung neoplasms (Other) / Tumor microenvironment (Other)},
      cin          = {C060 / A370},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)A370-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38614857},
      doi          = {10.1016/j.pulmoe.2024.03.003},
      url          = {https://inrepo02.dkfz.de/record/289462},
}