%0 Journal Article
%A Gwenzi, Tafirenyika
%A Schrotz-King, P.
%A Anker, S. C.
%A Schöttker, B.
%A Hoffmeister, M.
%A Brenner, Hermann
%T Post-operative C-reactive protein as a strong independent predictor of long-term colorectal cancer outcomes: consistent findings from two large patient cohorts.
%J ESMO open
%V 9
%N 4
%@ 2059-7029
%C London
%I BMJ
%M DKFZ-2024-00785
%P 102982
%D 2024
%Z #EA:C120#LA:C120#LA:C070#
%X Post-surgery blood-based biomarkers may be useful for guiding treatment and surveillance decisions among colorectal cancer (CRC) patients. However, most candidate biomarkers provide little if any predictive value beyond stage at diagnosis. We aimed to investigate the independent prognostic value of post-operative serum C-reactive protein (CRP), a highly sensitive biomarker of inflammation, for long-term CRC outcomes in two large patient cohorts.CRP levels were measured from serum samples of CRC patients collected ≥1 month post-surgery in the German DACHS (n = 1416) and the UK Biobank (n = 1149) cohorts. Associations of post-operative CRP with overall survival (OS) and CRC-specific survival (CSS) were assessed using Cox regression and presented as hazard ratios (HRs) with 95
%K C-reactive protein (Other)
%K colorectal (Other)
%K prognosis (Other)
%K survival (Other)
%K systemic inflammation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38613909
%R 10.1016/j.esmoop.2024.102982
%U https://inrepo02.dkfz.de/record/289463