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@ARTICLE{Gwenzi:289463,
      author       = {T. Gwenzi$^*$ and P. Schrotz-King$^*$ and S. C. Anker and
                      B. Schöttker$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{P}ost-operative {C}-reactive protein as a strong
                      independent predictor of long-term colorectal cancer
                      outcomes: consistent findings from two large patient
                      cohorts.},
      journal      = {ESMO open},
      volume       = {9},
      number       = {4},
      issn         = {2059-7029},
      address      = {London},
      publisher    = {BMJ},
      reportid     = {DKFZ-2024-00785},
      pages        = {102982},
      year         = {2024},
      note         = {#EA:C120#LA:C120#LA:C070#},
      abstract     = {Post-surgery blood-based biomarkers may be useful for
                      guiding treatment and surveillance decisions among
                      colorectal cancer (CRC) patients. However, most candidate
                      biomarkers provide little if any predictive value beyond
                      stage at diagnosis. We aimed to investigate the independent
                      prognostic value of post-operative serum C-reactive protein
                      (CRP), a highly sensitive biomarker of inflammation, for
                      long-term CRC outcomes in two large patient cohorts.CRP
                      levels were measured from serum samples of CRC patients
                      collected ≥1 month post-surgery in the German DACHS (n =
                      1416) and the UK Biobank (n = 1149) cohorts. Associations of
                      post-operative CRP with overall survival (OS) and
                      CRC-specific survival (CSS) were assessed using Cox
                      regression and presented as hazard ratios (HRs) with $95\%$
                      confidence intervals (CIs), adjusted for key
                      sociodemographic and clinical covariates.In both cohorts,
                      consistent strong dose-response relationships between
                      post-operative CRP and both OS and CSS were observed.
                      Adjusted HRs $(95\%$ CI) for CRP >10 versus <3 mg/l were
                      1.93 (1.58-2.35) and 2.70 (2.03-3.59) in the DACHS cohort,
                      and 2.70 (1.96-3.71) and 2.61 (1.83-3.72) in the UK Biobank
                      cohort, respectively. Associations between post-operative
                      CRP and OS were particularly strong among younger patients
                      (<65 years at diagnosis; P value for interaction by age
                      <0.01).Serum CRP determined a month or more after surgery
                      may be useful as a strong independent prognostic biomarker
                      for guiding therapeutic decisions and for surveillance of
                      the course of disease of CRC patients, particularly those
                      <65 years of age at diagnosis.},
      keywords     = {C-reactive protein (Other) / colorectal (Other) / prognosis
                      (Other) / survival (Other) / systemic inflammation (Other)},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38613909},
      doi          = {10.1016/j.esmoop.2024.102982},
      url          = {https://inrepo02.dkfz.de/record/289463},
}