000289486 001__ 289486
000289486 005__ 20240508085855.0
000289486 0247_ $$2doi$$a10.1021/acsnano.3c08335
000289486 0247_ $$2pmid$$apmid:38626916
000289486 0247_ $$2ISSN$$a1936-0851
000289486 0247_ $$2ISSN$$a1936-086X
000289486 0247_ $$2altmetric$$aaltmetric:162570334
000289486 037__ $$aDKFZ-2024-00808
000289486 041__ $$aEnglish
000289486 082__ $$a540
000289486 1001_ $$aHorvat, Natalie K$$b0
000289486 245__ $$aSuperparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment.
000289486 260__ $$aWashington, DC$$bSoc.$$c2024
000289486 3367_ $$2DRIVER$$aarticle
000289486 3367_ $$2DataCite$$aOutput Types/Journal article
000289486 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1715151447_22381
000289486 3367_ $$2BibTeX$$aARTICLE
000289486 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000289486 3367_ $$00$$2EndNote$$aJournal Article
000289486 500__ $$a#LA:B220# / 2024 Apr 30;18(17):11025-11041
000289486 520__ $$aALK-positive NSCLC patients demonstrate initial responses to ALK tyrosine kinase inhibitor (TKI) treatments, but eventually develop resistance, causing rapid tumor relapse and poor survival rates. Growing evidence suggests that the combination of drug and immune therapies greatly improves patient survival; however, due to the low immunogenicity of the tumors, ALK-positive patients do not respond to currently available immunotherapies. Tumor-associated macrophages (TAMs) play a crucial role in facilitating lung cancer growth by suppressing tumoricidal immune activation and absorbing chemotherapeutics. However, they can also be programmed toward a pro-inflammatory tumor suppressive phenotype, which represents a highly active area of therapy development. Iron loading of TAMs can achieve such reprogramming correlating with an improved prognosis in lung cancer patients. We previously showed that superparamagnetic iron oxide nanoparticles containing core-cross-linked polymer micelles (SPION-CCPMs) target macrophages and stimulate pro-inflammatory activation. Here, we show that SPION-CCPMs stimulate TAMs to secrete reactive nitrogen species and cytokines that exert tumoricidal activity. We further show that SPION-CCPMs reshape the immunosuppressive Eml4-Alk lung tumor microenvironment (TME) toward a cytotoxic profile hallmarked by the recruitment of CD8+ T cells, suggesting a multifactorial benefit of SPION-CCPM application. When intratracheally instilled into lung cancer-bearing mice, SPION-CCPMs delay tumor growth and, after first line therapy with a TKI, halt the regrowth of relapsing tumors. These findings identify SPIONs-CCPMs as an adjuvant therapy, which remodels the TME, resulting in a delay in the appearance of resistant tumors.
000289486 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
000289486 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000289486 650_7 $$2Other$$aadjuvant therapy
000289486 650_7 $$2Other$$airon homeostasis
000289486 650_7 $$2Other$$alung cancer
000289486 650_7 $$2Other$$ananoparticle
000289486 650_7 $$2Other$$apolymeric micelle
000289486 7001_ $$0P:(DE-HGF)0$$aChocarro, Sara$$b1
000289486 7001_ $$aMarques, Oriana$$b2
000289486 7001_ $$aBauer, Tobias A$$b3
000289486 7001_ $$aQiu, Ruiyue$$b4
000289486 7001_ $$0P:(DE-HGF)0$$aDiaz-Jimenez, Alberto$$b5
000289486 7001_ $$0P:(DE-He78)1c49e2bc4134e93b5dc7d9845e30c039$$aHelm, Barbara$$b6$$udkfz
000289486 7001_ $$0P:(DE-He78)cb1c1075d6ce2a1d20a7c74232e56c18$$aChen, Yuanyuan$$b7
000289486 7001_ $$0P:(DE-He78)14909c75431f33f953a7ab4ad3bd7d51$$aSawall, Stefan$$b8$$udkfz
000289486 7001_ $$aSparla, Richard$$b9
000289486 7001_ $$00000-0001-8207-756X$$aSu, Lu$$b10
000289486 7001_ $$0P:(DE-He78)860df4ab16c373fb28a815dcd81107a6$$aKlingmüller, Ursula$$b11$$udkfz
000289486 7001_ $$00000-0002-1749-9034$$aBarz, Matthias$$b12
000289486 7001_ $$aHentze, Matthias W$$b13
000289486 7001_ $$0P:(DE-HGF)0$$aSotillo, Rocío$$b14$$eLast author
000289486 7001_ $$aMuckenthaler, Martina U$$b15
000289486 773__ $$0PERI:(DE-600)2383064-5$$a10.1021/acsnano.3c08335$$gp. acsnano.3c08335$$n17$$p11025-11041$$tACS nano$$v18$$x1936-0851$$y2024
000289486 909CO $$ooai:inrepo02.dkfz.de:289486$$pVDB
000289486 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000289486 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000289486 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)1c49e2bc4134e93b5dc7d9845e30c039$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000289486 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)cb1c1075d6ce2a1d20a7c74232e56c18$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ
000289486 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)14909c75431f33f953a7ab4ad3bd7d51$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000289486 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)860df4ab16c373fb28a815dcd81107a6$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000289486 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000289486 9131_ $$0G:(DE-HGF)POF4-312$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunktionelle und strukturelle Genomforschung$$x0
000289486 9141_ $$y2024
000289486 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bACS NANO : 2022$$d2023-10-25
000289486 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bACS NANO : 2022$$d2023-10-25
000289486 9202_ $$0I:(DE-He78)B220-20160331$$kB220$$lB220 Molekulare Grundlagen thorakaler Tumoren$$x0
000289486 9201_ $$0I:(DE-He78)B220-20160331$$kB220$$lB220 Molekulare Grundlagen thorakaler Tumoren$$x0
000289486 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000289486 9201_ $$0I:(DE-He78)B200-20160331$$kB200$$lB200 Systembiologie der Signaltransduktion$$x2
000289486 9201_ $$0I:(DE-He78)E025-20160331$$kE025$$lE025 Röntgenbildgebung und Computertomographie$$x3
000289486 980__ $$ajournal
000289486 980__ $$aVDB
000289486 980__ $$aI:(DE-He78)B220-20160331
000289486 980__ $$aI:(DE-He78)HD01-20160331
000289486 980__ $$aI:(DE-He78)B200-20160331
000289486 980__ $$aI:(DE-He78)E025-20160331
000289486 980__ $$aUNRESTRICTED