TY  - JOUR
AU  - Huang, Jesse
AU  - Tengvall, Katarina
AU  - Bomfim Lima, Izaura
AU  - Hedström, Anna Karin
AU  - Butt, Julia Anna
AU  - Brenner, Nicole
AU  - Gyllenberg, Alexandra
AU  - Stridh, Pernilla
AU  - Khademi, Mohsen
AU  - Ernberg, Ingemar
AU  - Al Nimer, Faiez
AU  - Manouchehrinia, Ali
AU  - Hillert, Jan
AU  - Alfredsson, Lars
AU  - Andersen, Oluf
AU  - Sundström, Peter
AU  - Waterboer, Tim
AU  - Olsson, Tomas
AU  - Kockum, Ingrid
TI  - Genetics of immune response to Epstein-Barr virus: prospects for multiple sclerosis pathogenesis.
JO  - Brain
VL  - 147
IS  - 10
SN  - 0006-8950
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2024-00821
SP  - 3573-3582
PY  - 2024
N1  - 2024 Oct 3;147(10):3573-3582
AB  - Epstein-Barr virus (EBV) infection has been advocated as a prerequisite for developing multiple sclerosis (MS) and possibly the propagation of the disease. However, the precise mechanisms for such influences are still unclear. A large-scale study investigating the host genetics of EBV serology and related clinical manifestations, such as infectious mononucleosis (IM), may help us better understand the role of EBV in MS pathogenesis. This study evaluates the host genetic factors that influence serological response against EBV and history of IM and cross-evaluates them with MS risk and genetic susceptibility in the Swedish population. Plasma IgG antibody levels against EBV nuclear antigen-1 (EBNA-1, truncated=aa[325-641], peptide=aa[385-420]) and viral capsid antigen p18 (VCAp18) were measured using bead-based multiplex serology for 8744 MS cases and 7229 population-matched controls. The MS risk association for high/low EBV antibody levels and history of IM was compared to relevant clinical measures along with sex, age at sampling, and associated HLA allele variants. Genome-wide and HLA allele association analyses were also performed to identify genetic risk factors for EBV antibody response and IM history. Higher antibody levels against VCAp18 (OR=1.74, 95
KW  - DRB1 (Other)
KW  - EBNA1 (Other)
KW  - EBV (Other)
KW  - GWAS (Other)
KW  - HLA (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38630618
DO  - DOI:10.1093/brain/awae110
UR  - https://inrepo02.dkfz.de/record/289499
ER  -