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000289597 1001_ $$aTran, Cong Si$$b0
000289597 245__ $$aPhosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells.
000289597 260__ $$aPhiladelphia, Pa. [u.a.]$$bSaunders$$c2024
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000289597 520__ $$aHigh expression of phosphatidylinositol 4-kinase III alpha (PI4KIIIα) correlates with poor survival rates in patients with hepatocellular carcinoma (HCC). In addition, Hepatitis C virus (HCV) infections activate PI4KIIIα and contribute to HCC progression. We aimed at mechanistically understanding the impact of PI4KIIIα on the progression of liver cancer and the potential contribution of HCV in this process.Several hepatic cell culture and mouse models were used to study functional importance of PI4KIIIα on liver pathogenesis. Antibody arrays, gene silencing and PI4KIIIα specific inhibitor were applied to identify the involved signaling pathways. The contribution of HCV was examined by using HCV infection or overexpression of its nonstructural protein.High PI4KIIIα expression and/or activity induced cytoskeletal rearrangements via increased-phosphorylation of paxillin and cofilin. This led to morphological alterations and higher migratory and invasive properties of liver cancer cells. We further identified the liver specific lipid kinase phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PIK3C2γ) working downstream of PI4KIIIα in regulation of the cytoskeleton. PIK3C2γ generates plasma membrane (PM) phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2]-enriched, invadopodia-like structures which regulate cytoskeletal reorganization by promoting Akt2 phosphorylation.PI4KIIIα regulates cytoskeleton organization via PIK3C2γ/Akt2/paxillin-cofilin to favor migration and invasion of liver cancer cells. These findings provide mechanistic insight into the contribution of PI4KIIIα and HCV to progression of liver cancer and identify promising targets for therapeutic intervention.
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000289597 650_7 $$2Other$$aAkt2
000289597 650_7 $$2Other$$aHCV
000289597 650_7 $$2Other$$aPIK3C2G
000289597 650_7 $$2Other$$ahepatocellular carcinoma
000289597 650_7 $$2Other$$aphospholipid
000289597 7001_ $$aKersten, Julia$$b1
000289597 7001_ $$aYan, Jingyi$$b2
000289597 7001_ $$0P:(DE-He78)a7f6241ee41dbfd09892f8027db893d0$$aBreinig, Marco$$b3$$udkfz
000289597 7001_ $$aHuth, Thorben$$b4
000289597 7001_ $$aPoth, Tanja$$b5
000289597 7001_ $$aColasanti, Ombretta$$b6
000289597 7001_ $$0P:(DE-He78)e4d7c2f391da716edc9beec6468f108f$$aRiedl, Tobias$$b7$$udkfz
000289597 7001_ $$aFaure-Dupuy, Suzanne$$b8
000289597 7001_ $$aDiehl, Stefan$$b9
000289597 7001_ $$aVerhoye, Lieven$$b10
000289597 7001_ $$aLi, Teng-Feng$$b11
000289597 7001_ $$aLingemann, Marit$$b12
000289597 7001_ $$aSchult, Philipp$$b13
000289597 7001_ $$aAhlén, Gustaf$$b14
000289597 7001_ $$aFrelin, Lars$$b15
000289597 7001_ $$aKühnel, Florian$$b16
000289597 7001_ $$aVondran, Florian W R$$b17
000289597 7001_ $$aBreuhahn, Kai$$b18
000289597 7001_ $$aMeuleman, Philip$$b19
000289597 7001_ $$aHeikenwälder, Mathias$$b20
000289597 7001_ $$aSchirmacher, Peter$$b21
000289597 7001_ $$0P:(DE-He78)1d3968d2f0ff3eae55f6b2ea4c474387$$aBartenschlager, Ralf$$b22$$udkfz
000289597 7001_ $$aLaketa, Vibor$$b23
000289597 7001_ $$aRoessler, Stephanie$$b24
000289597 7001_ $$0P:(DE-He78)ceccc9aed8c6e89c00795bce1f1d83a3$$aTschaharganeh, Darjus Felix$$b25$$udkfz
000289597 7001_ $$aSällberg, Matti$$b26
000289597 7001_ $$aLohmann, Volker$$b27
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