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@ARTICLE{PeruchetNoray:289650,
      author       = {L. Peruchet-Noray and A. M. Sedlmeier and N. Dimou and H.
                      Baurecht and B. Fervers and E. Fontvieille and J. Konzok and
                      K. K. Tsilidis and S. Christakoudi and A. Jansana and R.
                      Cordova and P. Bohmann and M. J. Stein and A. Weber and S.
                      Bézieau and H. Brenner$^*$ and A. T. Chan and I. Cheng and
                      J. C. Figueiredo and K. Garcia-Etxebarria and V. Moreno and
                      C. C. Newton and S. L. Schmit and M. Song and C. M. Ulrich
                      and P. Ferrari and V. Viallon and R. Carreras-Torres and M.
                      J. Gunter and H. Freisling},
      title        = {{T}issue-specific genetic variation suggests distinct
                      molecular pathways between body shape phenotypes and
                      colorectal cancer.},
      journal      = {Science advances},
      volume       = {10},
      number       = {16},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2024-00832},
      pages        = {eadj1987},
      year         = {2024},
      abstract     = {It remains unknown whether adiposity subtypes are
                      differentially associated with colorectal cancer (CRC). To
                      move beyond single-trait anthropometric indicators, we
                      derived four multi-trait body shape phenotypes reflecting
                      adiposity subtypes from principal components analysis on
                      body mass index, height, weight, waist-to-hip ratio, and
                      waist and hip circumference. A generally obese (PC1) and a
                      tall, centrally obese (PC3) body shape were both positively
                      associated with CRC risk in observational analyses in
                      329,828 UK Biobank participants (3728 cases). In genome-wide
                      association studies in 460,198 UK Biobank participants, we
                      identified 3414 genetic variants across four body shapes and
                      Mendelian randomization analyses confirmed positive
                      associations of PC1 and PC3 with CRC risk (52,775
                      cases/45,940 controls from GECCO/CORECT/CCFR). Brain
                      tissue-specific genetic instruments, mapped to PC1 through
                      enrichment analysis, were responsible for the relationship
                      between PC1 and CRC, while the relationship between PC3 and
                      CRC was predominantly driven by adipose tissue-specific
                      genetic instruments. This study suggests distinct putative
                      causal pathways between adiposity subtypes and CRC.},
      cin          = {C070 / C120 / HD01},
      ddc          = {500},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38640244},
      pmc          = {pmc:PMC11029802},
      doi          = {10.1126/sciadv.adj1987},
      url          = {https://inrepo02.dkfz.de/record/289650},
}