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@ARTICLE{LaPorta:289800,
      author       = {C. La Porta and T. Plum$^*$ and R. Palme and M. Mack and A.
                      Tappe-Theodor},
      title        = {{R}epeated social defeat stress differently affects
                      arthritis-associated hypersensitivity in male and female
                      mice.},
      journal      = {Brain, behavior and immunity},
      volume       = {119},
      issn         = {0889-1591},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2024-00879},
      pages        = {572-596},
      year         = {2024},
      note         = {2024 Apr 23:119:572-596},
      abstract     = {Chronic stress enhances the risk of neuropsychiatric
                      disorders and contributes to the aggravation and chronicity
                      of pain. The development of stress-associated diseases,
                      including pain, is affected by individual vulnerability or
                      resilience to stress, although the mechanisms remain
                      elusive. We used the repeated social defeat stress model
                      promoting susceptible and resilient phenotypes in male and
                      female mice and induced knee mono-arthritis to investigate
                      the impact of stress vulnerability on pain and immune system
                      regulation. We analyzed different pain-related behaviors,
                      measured blood cytokine and immune cell levels, and
                      performed histological analyses at the knee joints and
                      pain/stress-related brain areas. Stress susceptible male and
                      female mice showed prolonged arthritis-associated
                      hypersensitivity. Interestingly, hypersensitivity was
                      exacerbated in male but not female mice. In males, stress
                      promoted transiently increased neutrophils and Ly6Chigh
                      monocytes, lasting longer in susceptible than resilient
                      mice. While resilient male mice displayed persistently
                      increased levels of the anti-inflammatory interleukin
                      (IL)-10, susceptible mice showed increased levels of the
                      pro-inflammatory IL-6 at the early- and IL-12 at the late
                      arthritis stage. Although joint inflammation levels were
                      comparable among groups, macrophage and neutrophil
                      infiltration was higher in the synovium of susceptible mice.
                      Notably, only susceptible male mice, but not females,
                      presented microgliosis and monocyte infiltration in the
                      prefrontal cortex at the late arthritis stage. Blood
                      Ly6Chigh monocyte depletion during the early inflammatory
                      phase abrogated late-stage hypersensitivity and the
                      associated histological alterations in susceptible male
                      mice. Thus, recruitment of blood Ly6Chigh monocytes during
                      the early arthritis phase might be a key factor mediating
                      the persistence of arthritis pain in susceptible male mice.
                      Alternative neuro-immune pathways that remain to be explored
                      might be involved in females.},
      keywords     = {Arthritis (Other) / Cytokines (Other) / Microglia (Other) /
                      Monocytes (Other) / Neutrophils (Other) / Pain (Other) /
                      Social defeat (Other)},
      cin          = {D110},
      ddc          = {150},
      cid          = {I:(DE-He78)D110-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38663771},
      doi          = {10.1016/j.bbi.2024.04.025},
      url          = {https://inrepo02.dkfz.de/record/289800},
}