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@ARTICLE{Bosch:289801,
      author       = {T. C. G. Bosch and M. Wigley and B. Colomina and B.
                      Bohannan and F. Meggers and K. R. Amato and M. B. Azad and
                      M. J. Blaser and K. Brown and M. G. Dominguez-Bello and S.
                      D. Ehrlich and E. Elinav$^*$ and B. B. Finlay and K. Geddie
                      and N. Geva-Zatorsky and T. Giles-Vernick and P. Gros and K.
                      Guillemin and L.-P. Haraoui and E. Johnson and F. Keck and
                      J. Lorimer and M. J. McFall-Ngai and M. Nichter and S.
                      Pettersson and H. Poinar and T. Rees and C. Tropini and E.
                      A. Undurraga and L. Zhao and M. K. Melby},
      title        = {{T}he potential importance of the built-environment
                      microbiome and its impact on human health.},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {121},
      number       = {20},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {DKFZ-2024-00880},
      pages        = {e2313971121},
      year         = {2024},
      abstract     = {There is increasing evidence that interactions between
                      microbes and their hosts not only play a role in determining
                      health and disease but also in emotions, thought, and
                      behavior. Built environments greatly influence microbiome
                      exposures because of their built-in highly specific
                      microbiomes coproduced with myriad metaorganisms including
                      humans, pets, plants, rodents, and insects. Seemingly static
                      built structures host complex ecologies of microorganisms
                      that are only starting to be mapped. These microbial
                      ecologies of built environments are directly and
                      interdependently affected by social, spatial, and
                      technological norms. Advances in technology have made these
                      organisms visible and forced the scientific community and
                      architects to rethink gene-environment and microbe
                      interactions respectively. Thus, built environment design
                      must consider the microbiome, and research involving
                      host-microbiome interaction must consider the
                      built-environment. This paradigm shift becomes increasingly
                      important as evidence grows that contemporary built
                      environments are steadily reducing the microbial diversity
                      essential for human health, well-being, and resilience while
                      accelerating the symptoms of human chronic diseases
                      including environmental allergies, and other more
                      life-altering diseases. New models of design are required to
                      balance maximizing exposure to microbial diversity while
                      minimizing exposure to human-associated diseases. Sustained
                      trans-disciplinary research across time (evolutionary,
                      historical, and generational) and space (cultural and
                      geographical) is needed to develop experimental design
                      protocols that address multigenerational multispecies health
                      and health equity in built environments.},
      keywords     = {Humans / Built Environment / Microbiota: physiology /
                      Animals / Anthropocene (Other) / architectural design
                      (Other) / evolution (Other) / metaorganism (Other) /
                      microbiome (Other)},
      cin          = {D480 / F220},
      ddc          = {500},
      cid          = {I:(DE-He78)D480-20160331 / I:(DE-He78)F220-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38662573},
      doi          = {10.1073/pnas.2313971121},
      url          = {https://inrepo02.dkfz.de/record/289801},
}