TY  - JOUR
AU  - Lv, Siyao
AU  - Ding, Yunyi
AU  - Huang, Junli
AU  - He, Yixin
AU  - Xie, Ruijie
AU  - Shi, Xiaohong
AU  - Ye, Wei
TI  - Genetic prediction of micronutrient levels and the risk of colorectal polyps: A mendelian randomization study.
JO  - Clinical nutrition
VL  - 43
IS  - 6
SN  - 0261-5614
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2024-00917
SP  - 1405 - 1413
PY  - 2024
AB  - Previous epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on the risk of colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe the link between 13 human micronutrients (calcium, selenium, magnesium, phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene, iron, zinc, and copper) and the genetic susceptibility to CP.Summary statistics for CP (n = 463,010) were obtained from pan-European genome-wide association studies, and instrumental variables for 13 micronutrients were screened from published genome-wide association studies (GWAS). After selecting suitable instrumental variables, we performed a two-sample MR study, deploying sensitivity analyses to judge heterogeneity and pleiotropy, using inverse variance weighted methods as our primary estimation tool.Our study identified that a genetic predisposition to elevated toenail and circulating selenium or serum β-carotene concentrations lowers the risk of CP occurrence. However, no statistically significant association was observed between the other 11 micronutrients and the risk of CP.The study findings provide evidence that the micronutrient selenium and β-carotene may confer protective effects against the development of CP.
KW  - Colorectal polyps (Other)
KW  - Mendelian randomization study (Other)
KW  - Nutrition (Other)
KW  - Risk factors (Other)
KW  - Selenium (Other)
KW  - β-carotene (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38691983
DO  - DOI:10.1016/j.clnu.2024.04.019
UR  - https://inrepo02.dkfz.de/record/289934
ER  -