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@ARTICLE{Lv:289934,
      author       = {S. Lv and Y. Ding and J. Huang and Y. He and R. Xie$^*$ and
                      X. Shi and W. Ye},
      title        = {{G}enetic prediction of micronutrient levels and the risk
                      of colorectal polyps: {A} mendelian randomization study.},
      journal      = {Clinical nutrition},
      volume       = {43},
      number       = {6},
      issn         = {0261-5614},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-00917},
      pages        = {1405 - 1413},
      year         = {2024},
      abstract     = {Previous epidemiological and experimental studies have
                      yielded conflicting results regarding the influence of human
                      micronutrient levels on the risk of colorectal polyps (CP).
                      In our study, we conducted a two-sample Mendelian
                      randomization (MR) investigation to probe the link between
                      13 human micronutrients (calcium, selenium, magnesium,
                      phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene,
                      iron, zinc, and copper) and the genetic susceptibility to
                      CP.Summary statistics for CP (n = 463,010) were obtained
                      from pan-European genome-wide association studies, and
                      instrumental variables for 13 micronutrients were screened
                      from published genome-wide association studies (GWAS). After
                      selecting suitable instrumental variables, we performed a
                      two-sample MR study, deploying sensitivity analyses to judge
                      heterogeneity and pleiotropy, using inverse variance
                      weighted methods as our primary estimation tool.Our study
                      identified that a genetic predisposition to elevated toenail
                      and circulating selenium or serum β-carotene concentrations
                      lowers the risk of CP occurrence. However, no statistically
                      significant association was observed between the other 11
                      micronutrients and the risk of CP.The study findings provide
                      evidence that the micronutrient selenium and β-carotene may
                      confer protective effects against the development of CP.},
      keywords     = {Colorectal polyps (Other) / Mendelian randomization study
                      (Other) / Nutrition (Other) / Risk factors (Other) /
                      Selenium (Other) / β-carotene (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38691983},
      doi          = {10.1016/j.clnu.2024.04.019},
      url          = {https://inrepo02.dkfz.de/record/289934},
}