TY  - JOUR
AU  - Klotz, Laura Valentina
AU  - Casjens, Swaantje
AU  - Johnen, Georg
AU  - Taeger, Dirk
AU  - Brik, Alexander
AU  - Eichhorn, Florian
AU  - Förster, Laura
AU  - Kaiser, Nina
AU  - Muley, Thomas
AU  - Stolp, Christa
AU  - Schneider, Marc
AU  - Gleichenhagen, Jan
AU  - Brüning, Thomas
AU  - Winter, Hauke
AU  - Eichhorn, Martin
AU  - Weber, Daniel G
TI  - Combination of calretinin, MALAT1, and GAS5 as a potential prognostic biomarker to predict disease progression in surgically treated mesothelioma patients.
JO  - Lung cancer
VL  - 192
SN  - 0169-5002
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2024-00918
SP  - 107802
PY  - 2024
N1  - #EA:B220# / 2024 Jun;192:107802
AB  - The role of cytoreductive surgery for epithelioid pleural mesothelioma within a multimodal treatment approach remains controversial. Carefully selected patients benefit from cytoreductive surgery and adjuvant chemotherapy, but there is no established biomarker to predict tumor recurrence or progression during the course of the disease. The aim of this study was to identify potential biomarkers to predict therapeutic response in terms of progression-free survival.Between 03/2014 and 08/2022, preoperative blood samples were collected from 76 patients with epithelioid pleural mesothelioma who underwent cytoreductive surgery as part of a multimodal treatment approach. Identification of potential biomarkers was performed by determination of mesothelin and calretinin, as well as specific long non-coding RNAs and microRNAs. Receiver operating characteristic analysis, Kaplan-Meier survival analysis, and Cox regression were used to assess the association between biomarker concentrations and patient recurrence status and survival.MALAT1, GAS5, and calretinin showed statistically significant increased biomarker levels in patients with recurrence in contrast to recurrence-free patients after surgical treatment (p < 0.0001, p = 0.0190, and p = 0.0068, respectively). The combination of the three biomarkers resulted in a sensitivity of 68 
KW  - Biomarker (Other)
KW  - Calretinin (Other)
KW  - Cytoreductive surgery (Other)
KW  - Decortication (Other)
KW  - GAS5 (Other)
KW  - MALAT1 (Other)
KW  - Mesothelioma (Other)
KW  - Thoracic surgery (Other)
KW  - Tumor recurrence (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38692217
DO  - DOI:10.1016/j.lungcan.2024.107802
UR  - https://inrepo02.dkfz.de/record/289935
ER  -