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@ARTICLE{Klotz:289935,
      author       = {L. V. Klotz$^*$ and S. Casjens and G. Johnen and D. Taeger
                      and A. Brik and F. Eichhorn and L. Förster and N. Kaiser
                      and T. Muley and C. Stolp and M. Schneider and J.
                      Gleichenhagen and T. Brüning and H. Winter and M. Eichhorn
                      and D. G. Weber},
      title        = {{C}ombination of calretinin, {MALAT}1, and {GAS}5 as a
                      potential prognostic biomarker to predict disease
                      progression in surgically treated mesothelioma patients.},
      journal      = {Lung cancer},
      volume       = {192},
      issn         = {0169-5002},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-00918},
      pages        = {107802},
      year         = {2024},
      note         = {#EA:B220# / 2024 Jun;192:107802},
      abstract     = {The role of cytoreductive surgery for epithelioid pleural
                      mesothelioma within a multimodal treatment approach remains
                      controversial. Carefully selected patients benefit from
                      cytoreductive surgery and adjuvant chemotherapy, but there
                      is no established biomarker to predict tumor recurrence or
                      progression during the course of the disease. The aim of
                      this study was to identify potential biomarkers to predict
                      therapeutic response in terms of progression-free
                      survival.Between 03/2014 and 08/2022, preoperative blood
                      samples were collected from 76 patients with epithelioid
                      pleural mesothelioma who underwent cytoreductive surgery as
                      part of a multimodal treatment approach. Identification of
                      potential biomarkers was performed by determination of
                      mesothelin and calretinin, as well as specific long
                      non-coding RNAs and microRNAs. Receiver operating
                      characteristic analysis, Kaplan-Meier survival analysis, and
                      Cox regression were used to assess the association between
                      biomarker concentrations and patient recurrence status and
                      survival.MALAT1, GAS5, and calretinin showed statistically
                      significant increased biomarker levels in patients with
                      recurrence in contrast to recurrence-free patients after
                      surgical treatment (p < 0.0001, p = 0.0190, and p = 0.0068,
                      respectively). The combination of the three biomarkers
                      resulted in a sensitivity of 68 $\%$ and a specificity of 89
                      $\%.MALAT1,$ GAS5, and calretinin could be potential
                      biomarkers for the prediction of tumor recurrence, improving
                      the benefit from multimodal treatment including
                      cytoreductive surgery.},
      keywords     = {Biomarker (Other) / Calretinin (Other) / Cytoreductive
                      surgery (Other) / Decortication (Other) / GAS5 (Other) /
                      MALAT1 (Other) / Mesothelioma (Other) / Thoracic surgery
                      (Other) / Tumor recurrence (Other)},
      cin          = {B220},
      ddc          = {610},
      cid          = {I:(DE-He78)B220-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38692217},
      doi          = {10.1016/j.lungcan.2024.107802},
      url          = {https://inrepo02.dkfz.de/record/289935},
}