TY  - JOUR
AU  - Becerra-Tomás, Nerea
AU  - Markozannes, Georgios
AU  - Cariolou, Margarita
AU  - Balducci, Katia
AU  - Vieira, Rita
AU  - Kiss, Sonia
AU  - Aune, Dagfinn
AU  - Greenwood, Darren C
AU  - Dossus, Laure
AU  - Copson, Ellen
AU  - Renehan, Andrew G
AU  - Bours, Martijn
AU  - Demark-Wahnefried, Wendy
AU  - Hudson, Melissa M
AU  - May, Anne M
AU  - Odedina, Folakemi T
AU  - Skinner, Roderick
AU  - Steindorf, Karen
AU  - Tjønneland, Anne
AU  - Velikova, Galina
AU  - Baskin, Monica L
AU  - Chowdhury, Rajiv
AU  - Hill, Lynette
AU  - Lewis, Sarah J
AU  - Seidell, Jaap
AU  - Weijenberg, Matty P
AU  - Krebs, John
AU  - Cross, Amanda J
AU  - Tsilidis, Konstantinos K
AU  - Chan, Doris S M
TI  - Post-diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.
JO  - International journal of cancer
VL  - 155
IS  - 3
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2024-00923
SP  - 400-425
PY  - 2024
N1  - 2024 Aug 1;155(3):400-425
AB  - The adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta-analysis on post-diagnosis adiposity measures (body mass index [BMI], waist circumference, waist-to-hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022. Random-effects meta-analyses were conducted when at least three studies had sufficient information. The quality of evidence was interpreted and graded by the Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel. We reviewed 124 observational studies (85 publications). Meta-analyses were possible for BMI and all-cause mortality, colorectal cancer-specific mortality, and cancer recurrence/disease-free survival. Non-linear meta-analysis indicated a reverse J-shaped association between BMI and colorectal cancer outcomes (nadir at BMI 28 kg/m2). The highest risk, relative to the nadir, was observed at both ends of the BMI distribution (18 and 38 kg/m2), namely 60
KW  - adiposity (Other)
KW  - colorectal cancer (Other)
KW  - evidence grading (Other)
KW  - systematic review (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38692659
DO  - DOI:10.1002/ijc.34905
UR  - https://inrepo02.dkfz.de/record/289940
ER  -