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@ARTICLE{BecerraToms:289940,
      author       = {N. Becerra-Tomás and G. Markozannes and M. Cariolou and K.
                      Balducci and R. Vieira and S. Kiss and D. Aune and D. C.
                      Greenwood and L. Dossus and E. Copson and A. G. Renehan and
                      M. Bours and W. Demark-Wahnefried and M. M. Hudson and A. M.
                      May and F. T. Odedina and R. Skinner and K. Steindorf$^*$
                      and A. Tjønneland and G. Velikova and M. L. Baskin and R.
                      Chowdhury and L. Hill and S. J. Lewis and J. Seidell and M.
                      P. Weijenberg and J. Krebs and A. J. Cross and K. K.
                      Tsilidis and D. S. M. Chan},
      title        = {{P}ost-diagnosis adiposity and colorectal cancer prognosis:
                      {A} {G}lobal {C}ancer {U}pdate {P}rogramme ({CUP} {G}lobal)
                      systematic literature review and meta-analysis.},
      journal      = {International journal of cancer},
      volume       = {155},
      number       = {3},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-00923},
      pages        = {400-425},
      year         = {2024},
      note         = {2024 Aug 1;155(3):400-425},
      abstract     = {The adiposity influence on colorectal cancer prognosis
                      remains poorly characterised. We performed a systematic
                      review and meta-analysis on post-diagnosis adiposity
                      measures (body mass index [BMI], waist circumference,
                      waist-to-hip ratio, weight) or their changes and colorectal
                      cancer outcomes. PubMed and Embase were searched through 28
                      February 2022. Random-effects meta-analyses were conducted
                      when at least three studies had sufficient information. The
                      quality of evidence was interpreted and graded by the Global
                      Cancer Update Programme (CUP Global) independent Expert
                      Committee on Cancer Survivorship and Expert Panel. We
                      reviewed 124 observational studies (85 publications).
                      Meta-analyses were possible for BMI and all-cause mortality,
                      colorectal cancer-specific mortality, and cancer
                      recurrence/disease-free survival. Non-linear meta-analysis
                      indicated a reverse J-shaped association between BMI and
                      colorectal cancer outcomes (nadir at BMI 28 kg/m2). The
                      highest risk, relative to the nadir, was observed at both
                      ends of the BMI distribution (18 and 38 kg/m2), namely
                      $60\%$ and $23\%$ higher risk for all-cause mortality;
                      $95\%$ and $26\%$ for colorectal cancer-specific mortality;
                      and $37\%$ and $24\%$ for cancer recurrence/disease-free
                      survival, respectively. The higher risk with low BMI was
                      attenuated in secondary analyses of RCTs (compared to cohort
                      studies), among studies with longer follow-up, and in women
                      suggesting potential methodological limitations and/or
                      altered physiological state. Descriptively synthesised
                      studies on other adiposity-outcome associations of interest
                      were limited in number and methodological quality. All the
                      associations were graded as limited (likelihood of
                      causality: no conclusion) due to potential methodological
                      limitations (reverse causation, confounding, selection
                      bias). Additional well-designed observational studies and
                      interventional trials are needed to provide further
                      clarification.},
      keywords     = {adiposity (Other) / colorectal cancer (Other) / evidence
                      grading (Other) / systematic review (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38692659},
      doi          = {10.1002/ijc.34905},
      url          = {https://inrepo02.dkfz.de/record/289940},
}