TY  - JOUR
AU  - Liang, Qunfeng
AU  - Mukama, Trasias
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Brenner, Hermann
AU  - Kharazmi, Elhamalsadat
AU  - Fallah, Mahdi
TI  - Longer Interval Between First Colonoscopy With Negative Findings for Colorectal Cancer and Repeat Colonoscopy.
JO  - JAMA oncology
VL  - 10
IS  - 7
SN  - 2374-2437
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DKFZ-2024-00932
SP  - 866-873
PY  - 2024
N1  - #EA:C120#LA:C120# / 2024 Jul 1;10(7):866-873
AB  - For individuals without a family history of colorectal cancer (CRC), colonoscopy screening every 10 years is recommended to reduce CRC incidence and mortality. However, debate exists about whether and for how long this 10-year interval could be safely expanded.To assess how many years after a first colonoscopy with findings negative for CRC a second colonoscopy can be performed.This cohort study leveraged Swedish nationwide register-based data to examine CRC diagnoses and CRC-specific mortality among individuals without a family history of CRC. The exposed group included individuals who had a first colonoscopy with findings negative for CRC at age 45 to 69 years between 1990 and 2016. The control group included individuals matched by sex, birth year, and baseline age (ie, the age of their matched exposed individual when the exposed individual's first colonoscopy with findings negative for CRC was performed). Individuals in the control group either did not have a colonoscopy during the follow-up or underwent colonoscopy that resulted in a CRC diagnosis. Up to 18 controls were matched with each exposed individual. Individuals were followed up from 1990 to 2018, and data were analyzed from November 2022 to November 2023.A first colonoscopy with findings negative for CRC, defined as a first colonoscopy without a diagnosis of colorectal polyp, adenoma, carcinoma in situ, or CRC before or within 6 months after screening.The primary outcomes were CRC diagnosis and CRC-specific death. The 10-year standardized incidence ratio and standardized mortality ratio were calculated to compare risks of CRC and CRC-specific death in the exposed and control groups based on different follow-up screening intervals.The sample included 110 074 individuals (65 147 females [59.2
LB  - PUB:(DE-HGF)16
C6  - pmid:38696176
DO  - DOI:10.1001/jamaoncol.2024.0827
UR  - https://inrepo02.dkfz.de/record/289950
ER  -