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000290040 1001_ $$aChong, Marvin Y$$b0
000290040 245__ $$aLongitudinal associations of diurnal rest-activity rhythms with fatigue, insomnia, and health-related quality of life in survivors of colorectal cancer up to 5 years post-treatment.
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000290040 520__ $$aThere is a growing population of survivors of colorectal cancer (CRC). Fatigue and insomnia are common symptoms after CRC, negatively influencing health-related quality of life (HRQoL). Besides increasing physical activity and decreasing sedentary behavior, the timing and patterns of physical activity and rest over the 24-h day (i.e. diurnal rest-activity rhythms) could also play a role in alleviating these symptoms and improving HRQoL. We investigated longitudinal associations of the diurnal rest-activity rhythm (RAR) with fatigue, insomnia, and HRQoL in survivors of CRC.In a prospective cohort study among survivors of stage I-III CRC, 5 repeated measurements were performed from 6 weeks up to 5 years post-treatment. Parameters of RAR, including mesor, amplitude, acrophase, circadian quotient, dichotomy index, and 24-h autocorrelation coefficient, were assessed by a custom MATLAB program using data from tri-axial accelerometers worn on the upper thigh for 7 consecutive days. Fatigue, insomnia, and HRQoL were measured by validated questionnaires. Confounder-adjusted linear mixed models were applied to analyze longitudinal associations of RAR with fatigue, insomnia, and HRQoL from 6 weeks until 5 years post-treatment. Additionally, intra-individual and inter-individual associations over time were separated.Data were available from 289 survivors of CRC. All RAR parameters except for 24-h autocorrelation increased from 6 weeks to 6 months post-treatment, after which they remained relatively stable. A higher mesor, amplitude, circadian quotient, dichotomy index, and 24-h autocorrelation were statistically significantly associated with less fatigue and better HRQoL over time. A higher amplitude and circadian quotient were associated with lower insomnia. Most of these associations appeared driven by both within-person changes over time and between-person differences in RAR parameters. No significant associations were observed for acrophase.In the first five years after CRC treatment, adhering to a generally more active (mesor) and consistent (24-h autocorrelation) RAR, with a pronounced peak activity (amplitude) and a marked difference between daytime and nighttime activity (dichotomy index) was found to be associated with lower fatigue, lower insomnia, and a better HRQoL. Future intervention studies are needed to investigate if restoring RAR among survivors of CRC could help to alleviate symptoms of fatigue and insomnia while enhancing their HRQoL.EnCoRe study NL6904 ( https://www.onderzoekmetmensen.nl/ ).
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000290040 650_7 $$2Other$$aColorectal cancer survivorship
000290040 650_7 $$2Other$$aDiurnal rest-activity rhythms
000290040 650_7 $$2Other$$aFatigue
000290040 650_7 $$2Other$$aHealth-related quality of life
000290040 650_7 $$2Other$$aInsomnia
000290040 650_2 $$2MeSH$$aHumans
000290040 650_2 $$2MeSH$$aSleep Initiation and Maintenance Disorders: therapy
000290040 650_2 $$2MeSH$$aQuality of Life
000290040 650_2 $$2MeSH$$aColorectal Neoplasms
000290040 650_2 $$2MeSH$$aMale
000290040 650_2 $$2MeSH$$aFemale
000290040 650_2 $$2MeSH$$aFatigue
000290040 650_2 $$2MeSH$$aMiddle Aged
000290040 650_2 $$2MeSH$$aProspective Studies
000290040 650_2 $$2MeSH$$aCircadian Rhythm: physiology
000290040 650_2 $$2MeSH$$aCancer Survivors: psychology
000290040 650_2 $$2MeSH$$aRest
000290040 650_2 $$2MeSH$$aAged
000290040 650_2 $$2MeSH$$aLongitudinal Studies
000290040 650_2 $$2MeSH$$aExercise
000290040 650_2 $$2MeSH$$aSurveys and Questionnaires
000290040 7001_ $$aFrenken, Koen G$$b1
000290040 7001_ $$aEussen, Simone J P M$$b2
000290040 7001_ $$aKoster, Annemarie$$b3
000290040 7001_ $$aPot, Gerda K$$b4
000290040 7001_ $$aBreukink, Stéphanie O$$b5
000290040 7001_ $$aJanssen-Heijnen, Maryska$$b6
000290040 7001_ $$aKeulen, Eric T P$$b7
000290040 7001_ $$aBijnens, Wouter$$b8
000290040 7001_ $$aBuffart, Laurien M$$b9
000290040 7001_ $$aMeijer, Kenneth$$b10
000290040 7001_ $$aScheer, Frank A J L$$b11
000290040 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b12$$udkfz
000290040 7001_ $$ade Vos-Geelen, Judith$$b13
000290040 7001_ $$aWeijenberg, Matty P$$b14
000290040 7001_ $$avan Roekel, Eline H$$b15
000290040 7001_ $$aBours, Martijn J L$$b16
000290040 773__ $$0PERI:(DE-600)2134691-4$$a10.1186/s12966-024-01601-x$$gVol. 21, no. 1, p. 51$$n1$$p51$$tInternational journal of behavioral nutrition and physical activity$$v21$$x1479-5868$$y2024
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