000290042 001__ 290042 000290042 005__ 20250826100848.0 000290042 0247_ $$2doi$$a10.1016/j.tcb.2024.04.001 000290042 0247_ $$2pmid$$apmid:38697898 000290042 0247_ $$2ISSN$$a0962-8924 000290042 0247_ $$2ISSN$$a1879-3088 000290042 0247_ $$2altmetric$$aaltmetric:163030165 000290042 037__ $$aDKFZ-2024-00947 000290042 041__ $$aEnglish 000290042 082__ $$a570 000290042 1001_ $$0P:(DE-He78)483ad6be7d7fe19e48db9cce86efd70e$$aNiehrs, Christof$$b0$$eFirst author$$udkfz 000290042 245__ $$aCilia as Wnt signaling organelles. 000290042 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2025 000290042 3367_ $$2DRIVER$$aarticle 000290042 3367_ $$2DataCite$$aOutput Types/Journal article 000290042 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1735908842_24192$$xReview Article 000290042 3367_ $$2BibTeX$$aARTICLE 000290042 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000290042 3367_ $$00$$2EndNote$$aJournal Article 000290042 500__ $$aDKFZ-ZMBH Alliance / Volume 35, Issue 1, January 2025, Pages 24-32 / #EA:A050#LA:A050# 000290042 520__ $$aCilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and, conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are present in flagella, primary cilia, and multicilia, where they transmit an intraciliary signal that is independent of β-catenin. Intraciliary Wnt signaling promotes ciliogenesis, affecting male fertility, adipogenesis, and mucociliary clearance. Wnt also stimulates the beating of motile cilia, highlighting that these nanomotors, too, are chemosensory. Intraciliary Wnt signaling employs a Wnt-protein phosphatase 1 (PP1) signaling axis, involving the canonical Wnt pathway's inhibition of glycogen synthase kinase 3 (GSK3) to repress PP1 activity. Collectively, these findings support that cilia are Wnt signaling organelles, with implications for ciliopathies and cancer. 000290042 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0 000290042 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de 000290042 650_7 $$2Other$$aGSK3 000290042 650_7 $$2Other$$aWnt 000290042 650_7 $$2Other$$acilia 000290042 650_7 $$2Other$$aciliary signaling 000290042 650_7 $$2Other$$aciliogenesis 000290042 7001_ $$0P:(DE-He78)924b790fb07c500ea0fee7d472888d96$$aDa Silva, Fabio$$b1 000290042 7001_ $$0P:(DE-He78)5b895ce811cc43507affc3795b4decab$$aSeidl, Carina$$b2$$eLast author$$udkfz 000290042 773__ $$0PERI:(DE-600)1498903-7$$a10.1016/j.tcb.2024.04.001$$gp. 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