TY  - JOUR
AU  - Niehrs, Christof
AU  - Da Silva, Fabio
AU  - Seidl, Carina
TI  - Cilia as Wnt signaling organelles.
JO  - Trends in cell biology
VL  - 35
IS  - 1
SN  - 0962-8924
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2024-00947
SP  - 24-32
PY  - 2025
N1  - DKFZ-ZMBH Alliance / Volume 35, Issue 1, January 2025, Pages 24-32 / #EA:A050#LA:A050#
AB  - Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and, conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are present in flagella, primary cilia, and multicilia, where they transmit an intraciliary signal that is independent of β-catenin. Intraciliary Wnt signaling promotes ciliogenesis, affecting male fertility, adipogenesis, and mucociliary clearance. Wnt also stimulates the beating of motile cilia, highlighting that these nanomotors, too, are chemosensory. Intraciliary Wnt signaling employs a Wnt-protein phosphatase 1 (PP1) signaling axis, involving the canonical Wnt pathway's inhibition of glycogen synthase kinase 3 (GSK3) to repress PP1 activity. Collectively, these findings support that cilia are Wnt signaling organelles, with implications for ciliopathies and cancer.
KW  - GSK3 (Other)
KW  - Wnt (Other)
KW  - cilia (Other)
KW  - ciliary signaling (Other)
KW  - ciliogenesis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38697898
DO  - DOI:10.1016/j.tcb.2024.04.001
UR  - https://inrepo02.dkfz.de/record/290042
ER  -