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@ARTICLE{Niehrs:290042,
      author       = {C. Niehrs$^*$ and F. Da Silva$^*$ and C. Seidl$^*$},
      title        = {{C}ilia as {W}nt signaling organelles.},
      journal      = {Trends in cell biology},
      volume       = {35},
      number       = {1},
      issn         = {0962-8924},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2024-00947},
      pages        = {24-32},
      year         = {2025},
      note         = {DKFZ-ZMBH Alliance / Volume 35, Issue 1, January 2025,
                      Pages 24-32 / #EA:A050#LA:A050#},
      abstract     = {Cilia and Wnt signaling have a complex relationship,
                      wherein Wnt regulates cilia and, conversely, cilia may
                      affect Wnt signaling. Recently, it was shown that Wnt
                      receptors are present in flagella, primary cilia, and
                      multicilia, where they transmit an intraciliary signal that
                      is independent of β-catenin. Intraciliary Wnt signaling
                      promotes ciliogenesis, affecting male fertility,
                      adipogenesis, and mucociliary clearance. Wnt also stimulates
                      the beating of motile cilia, highlighting that these
                      nanomotors, too, are chemosensory. Intraciliary Wnt
                      signaling employs a Wnt-protein phosphatase 1 (PP1)
                      signaling axis, involving the canonical Wnt pathway's
                      inhibition of glycogen synthase kinase 3 (GSK3) to repress
                      PP1 activity. Collectively, these findings support that
                      cilia are Wnt signaling organelles, with implications for
                      ciliopathies and cancer.},
      subtyp        = {Review Article},
      keywords     = {GSK3 (Other) / Wnt (Other) / cilia (Other) / ciliary
                      signaling (Other) / ciliogenesis (Other)},
      cin          = {A050},
      ddc          = {570},
      cid          = {I:(DE-He78)A050-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38697898},
      doi          = {10.1016/j.tcb.2024.04.001},
      url          = {https://inrepo02.dkfz.de/record/290042},
}