Home > Publications database > Cilia as Wnt signaling organelles. > print

001     290042
005     20250826100848.0
024 7 _ |a 10.1016/j.tcb.2024.04.001
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024 7 _ |a 0962-8924
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100 1 _ |a Niehrs, Christof
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245 _ _ |a Cilia as Wnt signaling organelles.
260 _ _ |a Amsterdam [u.a.]
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500 _ _ |a DKFZ-ZMBH Alliance / Volume 35, Issue 1, January 2025, Pages 24-32 / #EA:A050#LA:A050#
520 _ _ |a Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and, conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are present in flagella, primary cilia, and multicilia, where they transmit an intraciliary signal that is independent of β-catenin. Intraciliary Wnt signaling promotes ciliogenesis, affecting male fertility, adipogenesis, and mucociliary clearance. Wnt also stimulates the beating of motile cilia, highlighting that these nanomotors, too, are chemosensory. Intraciliary Wnt signaling employs a Wnt-protein phosphatase 1 (PP1) signaling axis, involving the canonical Wnt pathway's inhibition of glycogen synthase kinase 3 (GSK3) to repress PP1 activity. Collectively, these findings support that cilia are Wnt signaling organelles, with implications for ciliopathies and cancer.
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650 _ 7 |a GSK3
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650 _ 7 |a cilia
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650 _ 7 |a ciliary signaling
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650 _ 7 |a ciliogenesis
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700 1 _ |a Da Silva, Fabio
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700 1 _ |a Seidl, Carina
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773 _ _ |a 10.1016/j.tcb.2024.04.001
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856 4 _ |u https://inrepo02.dkfz.de/record/290042/files/1-s2.0-S0962892424000710-main.pdf
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