TY  - JOUR
AU  - Fu, Ruojin
AU  - Chen, Xuechen
AU  - Niedermaier, Tobias
AU  - Seum, Teresa
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Excess weight, polygenic risk score and findings of colorectal neoplasms at screening colonoscopy.
JO  - The American journal of gastroenterology
VL  - 119
IS  - 9
SN  - 0002-9270
CY  - Alphen aan den Rijn, The Netherlands
PB  - Wolters Kluwer Health, Inc.
M1  - DKFZ-2024-00948
SP  - 1913-1920
PY  - 2024
N1  - #EA:C070#LA:C070#LA:C120# / 119(9), pp. 1913-1920 , 2024
AB  - Excess weight is an established risk factor for colorectal cancer (CRC). However, evidence is lacking on how its impact varies by polygenic risk at different stages of colorectal carcinogenesis.We assessed the individual and joint associations of body mass index (BMI) and polygenic risk scores (PRSs) with findings of colorectal neoplasms among 4,784 participants of screening colonoscopy. Adjusted odds ratios (aORs) for excess weight derived by multiple logistic regression were converted to genetic risk equivalents (GREs) to quantify the impact of excess weight compared to genetic predisposition.Overweight and obesity (BMI 25-<30 and ≥30 kg/m2) were associated with increased risk of any colorectal neoplasm (aOR [95
LB  - PUB:(DE-HGF)16
C6  - pmid:38704818
DO  - DOI:10.14309/ajg.0000000000002853
UR  - https://inrepo02.dkfz.de/record/290043
ER  -