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@ARTICLE{Fu:290043,
      author       = {R. Fu$^*$ and X. Chen$^*$ and T. Niedermaier$^*$ and T.
                      Seum$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{E}xcess weight, polygenic risk score and findings of
                      colorectal neoplasms at screening colonoscopy.},
      journal      = {The American journal of gastroenterology},
      volume       = {119},
      number       = {9},
      issn         = {0002-9270},
      address      = {Alphen aan den Rijn, The Netherlands},
      publisher    = {Wolters Kluwer Health, Inc.},
      reportid     = {DKFZ-2024-00948},
      pages        = {1913-1920},
      year         = {2024},
      note         = {#EA:C070#LA:C070#LA:C120# / 119(9), pp. 1913-1920 , 2024},
      abstract     = {Excess weight is an established risk factor for colorectal
                      cancer (CRC). However, evidence is lacking on how its impact
                      varies by polygenic risk at different stages of colorectal
                      carcinogenesis.We assessed the individual and joint
                      associations of body mass index (BMI) and polygenic risk
                      scores (PRSs) with findings of colorectal neoplasms among
                      4,784 participants of screening colonoscopy. Adjusted odds
                      ratios (aORs) for excess weight derived by multiple logistic
                      regression were converted to genetic risk equivalents (GREs)
                      to quantify the impact of excess weight compared to genetic
                      predisposition.Overweight and obesity (BMI 25-<30 and ≥30
                      kg/m2) were associated with increased risk of any colorectal
                      neoplasm (aOR $[95\%$ CI] 1.26 [1.09-1.45] and 1.47
                      [1.24-1.75]). Obesity was associated with increased risk of
                      advanced colorectal neoplasm (aOR $[95\%$ CI] 1.46
                      [1.16-1.84]). Dose-response relationships were seen for the
                      PRS (stronger for advanced neoplasms than any neoplasms),
                      with no interaction with BMI, suggesting multiplicative
                      effects of both factors. Obese participants with a PRS in
                      the highest tertile had a 2.3-fold $(95\%$ CI 1.7-3.1) and
                      2.9-fold $(95\%CI$ 1.9-4.3) increased risk of any colorectal
                      neoplasm and advanced colorectal neoplasm, respectively. The
                      aOR of obesity translated into a GRE of 38, meaning that its
                      impact was estimated to be equivalent to the risk caused by
                      38 percentiles higher PRS for colorectal neoplasm.Excess
                      weight and polygenic risk are associated with increased risk
                      of colorectal neoplasms in a multiplicative manner.
                      Maintaining normal weight is estimated to have an equivalent
                      effect as having 38 percentiles lower PRS.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38704818},
      doi          = {10.14309/ajg.0000000000002853},
      url          = {https://inrepo02.dkfz.de/record/290043},
}