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@ARTICLE{Janssen:290075,
      author       = {M. Janssen and A. Leo and C. Wolf and M. Stenzinger and M.
                      Bartenschlager and J. Brandt and S. Sauer and M. Schmitt and
                      P. Dreger and R. F. Schlenk$^*$ and C. M. Denkinger and C.
                      Müller-Tidow},
      title        = {{T}reatment of chronic {COVID}-19 with
                      convalescent/postvaccination plasma in patients with
                      hematologic malignancies.},
      journal      = {International journal of cancer},
      volume       = {155},
      number       = {4},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-00974},
      pages        = {618-626},
      year         = {2024},
      note         = {2024 Aug 15;155(4):618-626},
      abstract     = {Immunocompromised patients are at high risk to fail
                      clearance of SARS-CoV-2. Prolonged COVID-19 constitutes a
                      health risk and a management problem as cancer treatments
                      often have to be disrupted. As SARS-CoV-2 evolves, new
                      variants of concern have emerged that evade available
                      monoclonal antibodies. Moreover, antiviral therapy promotes
                      SARS-CoV-2 escape mutations, particularly in
                      immunocompromised patients. These patients frequently suffer
                      from prolonged infection. No successful treatment has been
                      established for persistent COVID-19 infection. Here, we
                      report on a series of 21 immunocompromised patients with
                      COVID-19-most of them hematologic malignancies-treated with
                      plasma obtained from recently convalescent or vaccinated
                      donors or a combination thereof. Repeated dosing of
                      SARS-CoV-2-antibody-containing plasma could clear SARS-CoV-2
                      infection in 16 out of 21 immunocompromised patients even if
                      COVID-19-specific treatments failed to induce sustained
                      viral clearance or to improve clinical course of SARS-CoV-2
                      infection. Ten patients were major responders defined as an
                      increase delta(d)Ct of > = 5 after the first administration
                      of convalescent and/or vaccinated plasma (C/VP). On average,
                      SARS-CoV-2 PCR Ct values increased from a median value of
                      22.55 (IQR = 19.10-24.25) to a median value of 29.57 (IQR =
                      27.55-34.63; p = <.0001) in the major response subgroup.
                      Furthermore, when treated a second time with C/VP, even 4
                      out of 5 of the initial nonresponders showed an increase in
                      Ct-values from a median value of 23.13 (IQR = 17.75-28.05)
                      to a median value of 32.79 (IQR = 31.75-33.75; p = .013).
                      Our results suggest that C/VP could be a feasible treatment
                      of COVID-19 infection in patients with hematologic
                      malignancies who did not respond to antiviral treatment.},
      keywords     = {COVID‐19 (Other) / SARS‐CoV‐2‐antibody containing
                      plasma (Other) / prolonged SARS‐CoV‐2 infection (Other)},
      cin          = {W010},
      ddc          = {610},
      cid          = {I:(DE-He78)W010-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38721724},
      doi          = {10.1002/ijc.34988},
      url          = {https://inrepo02.dkfz.de/record/290075},
}