%0 Journal Article
%A Wankhede, Durgesh
%A Yuan, Tanwei
%A Kloor, Matthias
%A Halama, Niels
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Clinical significance of combined tumour-infiltrating lymphocytes and microsatellite instability status in colorectal cancer: a systematic review and network meta-analysis.
%J The lancet / Gastroenterology & Hepatology
%V 9
%N 7
%@ 2468-1253
%C London
%I Elsevier
%M DKFZ-2024-01003
%P 609-619
%D 2024
%Z #EA:C070#LA:C070# / 2024 Jul;9(7):609-619 / HI-TRON
%X Microsatellite instability (MSI) status and tumour-infiltrating lymphocytes (TIL) are established prognostic factors in colorectal cancer. Previous studies evaluating the combination of TIL and MSI status identified distinct colorectal cancer subtypes with unique prognostic associations. However, these studies were often limited by sample size, particularly for MSI-high (MSI-H) tumours, and there is no comprehensive summary of the available evidence. We aimed to review the literature to compare the survival outcomes associated with the subtypes derived from the integrated MSI-TIL classification in patients with colorectal cancer.In this systematic review and network meta-analysis, we searched PubMed, Embase, Scopus, and the Cochrane Library without language restrictions, for articles published between Jan 1, 1990, and March 13, 2024. Patient cohorts comparing different combinations of TIL (high or low) and MSI status (MSI or microsatellite stable [MSS]) in patients with surgically resected colorectal cancer were included. Studies were excluded if they focused on neoadjuvant therapy or on other immune markers such as B cells or macrophages. Methodological quality assessment was done with the Newcastle-Ottawa scale; data appraisal and extraction was done independently by two reviewers. Summary estimates were extracted from published reports. The primary outcomes were overall survival, disease-free survival, and cancer-specific survival. A frequentist network meta-analysis was done to compare hazard ratios (HRs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38734024
%R 10.1016/S2468-1253(24)00091-8
%U https://inrepo02.dkfz.de/record/290167